Structure Identification: |
Chem Biol Drug Des. 2011 Jul;78(1):94-100. | Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products.[Pubmed: 21457470] | METHODS AND RESULTS: Three natural products, 1,5-Diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-Diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity.
All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities.
Compound III with a furyl ring showed strong activities against plant pathogenic fungi.
CONCLUSIONS:
The IC(50) of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III(2) ) was 1.20 mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug. |
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