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1,5-Diphenylpentan-1-one
1,5-Diphenylpentan-1-one
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 1,5-Diphenylpentan-1-one
Price:
CAS No.: 39686-51-6
Catalog No.: CFN96862
Molecular Formula: C17H18O
Molecular Weight: 238.33 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Liquid
Source: The herbs of Stellera chamaejasme.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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Related Libraries
Biological Activity
Description: 1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
Targets: AChR
In vitro:
Pest Manag Sci. 2001 Mar;57(3):307-10.
Activity of the botanical aphicides 1,5-diphenyl-1-pentanone and 1,5-diphenyl-2-penten-1-one on two species of Aphididnae.[Pubmed: 11455662]
1,5-Diphenyl-1-pentanone (1,5-Diphenylpentan-1-one, A) and 1,5-diphenyl-2-penten-1-one (B) are natural products extracted for the first time from Stellera chamaejasme.
METHODS AND RESULTS:
Laboratory bioassay showed that the two products have strong contact activity and very good anti-feedant activity against Aphis gossypii and Schizaphis graminum. Both products showed dose-dependent relationships for both forms of activity against the two aphids, the contact activity of B being about twice that of A. Both products were inferior to methomyl in contact activity but superior in anti-feedant activity against the two aphids.
CONCLUSIONS:
This is the first report of aphicidal activity in these two compounds, which may represent a new class of aphicide.
1,5-Diphenylpentan-1-one Description
Source: The herbs of Stellera chamaejasme.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1959 mL 20.9793 mL 41.9586 mL 83.9173 mL 104.8966 mL
5 mM 0.8392 mL 4.1959 mL 8.3917 mL 16.7835 mL 20.9793 mL
10 mM 0.4196 mL 2.0979 mL 4.1959 mL 8.3917 mL 10.4897 mL
50 mM 0.0839 mL 0.4196 mL 0.8392 mL 1.6783 mL 2.0979 mL
100 mM 0.042 mL 0.2098 mL 0.4196 mL 0.8392 mL 1.049 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Biol Drug Des. 2011 Jul;78(1):94-100.
Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products.[Pubmed: 21457470]

METHODS AND RESULTS:
Three natural products, 1,5-Diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-Diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi.
CONCLUSIONS:
The IC(50) of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III(2) ) was 1.20 mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug.
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