11(13)-Dehydroivaxillin | CAS:87441-73-4

11(13)-Dehydroivaxillin

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Description:

11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.

Targets:

Antifection

In vivo:

J Enzyme Inhib Med Chem. 2009 Feb;24(1):247-50.

In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.[Pubmed: 18608780]

The whole plants of Carpesium genus are used in traditional medicine as anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. A previous study on Carpesium genus suggested that the antiplasmodial activity against Plasmodium falciparum was due to the existence of 11(13)-Dehydroivaxillin (DDV) from EtOAc extracts of C. ceruum (Compositae).
METHODS AND RESULTS:
Here, the antimalarial activity of 11(13)-Dehydroivaxillin was evaluated against Plasmodium berghei in mice. The LD(50) of the compound was determined as 51.2 mg/kg, while doses of 124 mg/kg and above were found to be lethal to mice. 11(13)-Dehydroivaxillin (2, 5, 10 mg/kg/day) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation and in an established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day.
CONCLUSIONS:
11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.

11(13)-Dehydroivaxillin Description

Source:	The herbs of Carpesium abrotanoides L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	11(13)-Dehydroivaxillin
Price:
CAS No.:	87441-73-4
Catalog No.:	CFN97438
Molecular Formula:	C₁₅H₂₀O₄
Molecular Weight:	264.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Carpesium abrotanoides L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antimalaric Compound Library Sesquiterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7836 mL	18.9179 mL	37.8358 mL	75.6716 mL	94.5895 mL
5 mM	0.7567 mL	3.7836 mL	7.5672 mL	15.1343 mL	18.9179 mL
10 mM	0.3784 mL	1.8918 mL	3.7836 mL	7.5672 mL	9.4589 mL
50 mM	0.0757 mL	0.3784 mL	0.7567 mL	1.5134 mL	1.8918 mL
100 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.7567 mL	0.9459 mL

CFN99286	Carabrolactone A	1187925-30-9	282.3	C₁₅H₂₂O₅
CFN97438	11(13)-Dehydroivaxillin	87441-73-4	264.3	C₁₅H₂₀O₄
CFN92791	Aeruginolactone	1005208-88-7	248.3	C₁₅H₂₀O₃
CFN91839	Eupalinolide O	2170228-67-6	418.4	C₂₂H₂₆O₈
CFN90381	Eupalinolide A	877822-41-8	462.49	C₂₄H₃₀O₉
CFN90382	Eupalinolide B	877822-40-7	462.49	C₂₄H₃₀O₉
CFN99435	Eupalinolide K	108657-10-9	362.4	C₂₀H₂₆O₆
CFN92956	4,15-Isoatriplicolide methylacrylate	133559-38-3	344.36	C₁₉H₂₀O₆
CFN92955	Isoatriplicolide tiglate	133559-39-4	358.39	C₂₀H₂₂O₆