14,15beta-Dihydroxyklaineanone | CAS:137359-82-1

14,15beta-Dihydroxyklaineanone

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Description:

14,15beta-Dihydroxyklaineanone is a plant growth inhibitor. It (IC(50) = 5 microM) shows anti-tumor promoting on tumor promoter-induced Epstein-Barr virus activation.

In vitro:

J Ethnopharmacol. 2002 Sep;82(1):55-8.

In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.[Pubmed: 12169407]

Some quassinoids (1-6) isolated previously as plant growth inhibitors from the leaves of Eurycoma longifolia Jack. (Simaroubaceae) were subjected to in vitro tests on anti-tumor promoting, antischistosomal and plasmodicidal activities.
METHODS AND RESULTS:
The most active compound for inhibition of tumor promoter-induced Epstein-Barr virus activation (anti-tumor promotion) was 14,15beta-Dihydroxyklaineanone (5, IC(50) = 5 microM). Longilactone (1) gave significant antischistosomal effect at a concentration of 200 microg/ml. 11-Dehydroklaineanone (3) and 15beta-O-acetyl-14-hydroxyklaineanone (6) showed potent plasmodicidal activity (IC(50) = 2 microg/ml).
CONCLUSIONS:
Thus it was suggested that E. longifolia possesses high medicinal values due to the occurrence of a variety of quassinoids.

14,15beta-Dihydroxyklaineanone Description

Source:	The herbs of Eurycoma longifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	14,15beta-Dihydroxyklaineanone
Price:	$368 / 5 mg
CAS No.:	137359-82-1
Catalog No.:	CFN93124
Molecular Formula:	C₂₀H₂₈O₈
Molecular Weight:	396.43 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Eurycoma longifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5225 mL	12.6126 mL	25.2251 mL	50.4503 mL	63.0628 mL
5 mM	0.5045 mL	2.5225 mL	5.045 mL	10.0901 mL	12.6126 mL
10 mM	0.2523 mL	1.2613 mL	2.5225 mL	5.045 mL	6.3063 mL
50 mM	0.0505 mL	0.2523 mL	0.5045 mL	1.009 mL	1.2613 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	0.5045 mL	0.6306 mL

CFN96419	Yadanzioside L	99132-97-5	726.72	C₃₄H₄₆O₁₇
CFN96420	Yadanzioside K	101559-98-2	768.76	C₃₆H₄₈O₁₈
CFN92980	13,18-Dehydroglaucarubinone	68703-94-6	492.52	C₂₅H₃₂O₁₀
CFN92979	(+)-Glaucarubinone	1259-86-5	494.53	C₂₅H₃₄O₁₀
CFN89335	Bruceine B	25514-29-8	480.46	C₂₃H₂₈O₁₁
CFN91974	Bruceine C	25514-30-1	564.58	C₂₈H₃₆O₁₂
CFN89336	Bruceantinol	53729-52-5	606.62	C₃₀H₃₈O₁₃
CFN95216	Bruceantinol B	1822332-33-1	550.6	C₂₇H₃₄O₁₂
CFN91971	Bruceantinol A	948038-36-6	592.59	C₂₉H₃₆O₁₃
CFN91973	Bruceine J	948038-38-8	508.51	C₂₅H₃₂O₁₁