14-Benzoylneoline | CAS:99633-05-3 | Manufacturer ChemFaces

14-Benzoylneoline

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Description:

14-Benzoylneoline is a natural product from Aconitum carmichaeli.

In vitro:

Anal Chem. 2014 May 20;86(10):4748-57.

Comparative normal/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaeli.[Pubmed: 24731167 ]

Cell membrane chromatography (CMC) derived from pathological tissues is ideal for screening specific components acting on specific diseases from complex medicines owing to the maximum simulation of in vivo drug-receptor interactions. However, there are no pathological tissue-derived CMC models that have ever been developed, as well as no visualized affinity comparison of potential active components between normal and pathological CMC columns.
METHODS AND RESULTS:
In this study, a novel comparative normal/failing rat myocardium CMC analysis system based on online column selection and comprehensive two-dimensional (2D) chromatography/monolithic column/time-of-flight mass spectrometry was developed for parallel comparison of the chromatographic behaviors on both normal and pathological CMC columns, as well as rapid screening of the specific therapeutic agents that counteract doxorubicin (DOX)-induced heart failure from Acontium carmichaeli (Fuzi). In total, 16 potential active alkaloid components with similar structures in Fuzi were retained on both normal and failing myocardium CMC models. Most of them had obvious decreases of affinities on failing myocardium CMC compared with normal CMC model except for four components, talatizamine (TALA), 14-acetyl-TALA, hetisine, and 14-Benzoylneoline. One compound TALA with the highest affinity was isolated for further in vitro pharmacodynamic validation and target identification to validate the screen results.
CONCLUSIONS:
Voltage-dependent K(+) channel was confirmed as a binding target of TALA and 14-acetyl-TALA with high affinities. The online high throughput comparative CMC analysis method is suitable for screening specific active components from herbal medicines by increasing the specificity of screened results and can also be applied to other biological chromatography models.

14-Benzoylneoline Description

Source:	The roots of Aconitum carmichaeli
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	14-Benzoylneoline
Price:
CAS No.:	99633-05-3
Catalog No.:	CFN96225
Molecular Formula:	C₃₁H₄₃NO₇
Molecular Weight:	541.7 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Aconitum carmichaeli
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.846 mL	9.2302 mL	18.4604 mL	36.9208 mL	46.151 mL
5 mM	0.3692 mL	1.846 mL	3.6921 mL	7.3842 mL	9.2302 mL
10 mM	0.1846 mL	0.923 mL	1.846 mL	3.6921 mL	4.6151 mL
50 mM	0.0369 mL	0.1846 mL	0.3692 mL	0.7384 mL	0.923 mL
100 mM	0.0185 mL	0.0923 mL	0.1846 mL	0.3692 mL	0.4615 mL

CFN89456	Carmichaenine B	2065228-60-4	439.54	C₂₃H₃₇NO₇
CFN98582	Delsoline	509-18-2	467.6	C₂₅H₄₁NO₇
CFN98581	Deltaline	6836-11-9	507.62	C₂₇H₄₁NO₈
CFN98587	Chasmanine	5066-78-4	451.6	C₂₅H₄₁NO₆
CFN90248	Aconine	509-20-6	499.60	C₂₅H₄₁NO₉
CFN89534	Deltatsine	92631-66-8	467.59	C₂₅H₄₁NO₇
CFN89537	14-Dehydrobrowniine	4829-56-5	465.57	C₂₅H₃₉NO₇
CFN91818	Lappaconine	23943-93-3	423.6	C₂₃H₃₇NO₆
CFN90360	Lannaconitine	32854-75-4	584.70	C₃₂H₄₄N₂O₈
CFN90361	Lappaconitine Hydrobromide	97792-45-5	665.61	C₃₂H₄₄N₂O₈.HBr