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19-Oxocinobufotalin
19-Oxocinobufotalin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 19-Oxocinobufotalin
Price: $413 / 5mg
CAS No.: 24512-60-5
Catalog No.: CFN91016
Molecular Formula: C26H32O8
Molecular Weight: 472.53 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The glandular body of Bufo bufo gargarizans Cantor.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $318 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 19-Oxocinobufotalin 3-adipoylarginine ester shows significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
In vitro:
J Asian Nat Prod Res. 2011 Feb;13(2):111-6.
Cytotoxic constituents from the skin of the toad Bufo bufo gargarizans.[Pubmed: 21279874 ]

METHODS AND RESULTS:
To study the chemical composition of the skin of Bufo bufo gargarizans, various chromatographic methods were used in the isolation procedures and the structures of isolated compounds were determined based on NMR and MS analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as N-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-N-methylurea (1) and 19-Oxocinobufotalin 3-adipoylarginine ester (2), together with 11 known compounds.
CONCLUSIONS:
Isolated bufadienolides showed significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
19-Oxocinobufotalin Description
Source: The glandular body of Bufo bufo gargarizans Cantor.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1163 mL 10.5813 mL 21.1627 mL 42.3254 mL 52.9067 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL 8.4651 mL 10.5813 mL
10 mM 0.2116 mL 1.0581 mL 2.1163 mL 4.2325 mL 5.2907 mL
50 mM 0.0423 mL 0.2116 mL 0.4233 mL 0.8465 mL 1.0581 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4233 mL 0.5291 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Helvetica Chimica Acta, 1969, 52(4):1097–1101.
über neue Bufadienolide aus Ch'an Su. über Krötengifte, 34. Mitteilung.[Reference: WebLink]
Two new bufadienolides, isolated from Ch'an Su, are proved to be 19-Oxocinobufagin (III) and 19-Oxocinobufotalin (V), respectively.
CFN91013Resibufagin20987-24-0398.49C24H30O5
CFN90579Deacetylcinobufagin4026-95-3400.52C24H32O5
CFN98544Cinobufagin470-37-1442.55C26H34O6
CFN9101219-Oxocinobufagin24512-59-2456.53C26H32O7
CFN93070Marinobufagenin470-42-8400.51C24H32O5
CFN93073Desacetylcinobufotalin4099-30-3416.51C24H32O6
CFN90137Cinobufotalin1108-68-5458.54C26H34O7
CFN91051Cinobufaginol6691-83-4458.55C26H34O7
CFN9101619-Oxocinobufotalin24512-60-5472.53C26H32O8
CFN90957Arenobufagin 3-hemisuberate30219-16-0572.69C32H44O9
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