1beta,10beta-Epoxydesacetoxymatricarin | CAS:124020-39-9

1beta,10beta-Epoxydesacetoxymatricarin

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Description:

1beta,10beta-Epoxydesacetoxymatricarin shows high anti-hypercholesterolemic potential.

Targets:

HMG-CoA Reductase | TNF-α | MMP(e.g.TIMP)

In vivo:

Molecules. 2016 Mar 25;21(4):404.

The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed: 27023504 ]

This study was done to identify the content compounds of Achillea wilhelmsii (A. wilhelmsii) and to evaluate its hypoglycemic and anti-hypercholesterolemic activity and effect on inflammatory mediators.
METHODS AND RESULTS:
The extracts and fractions of A. wilhelmsii were thoroughly analyzed using high performance liquid chromatography (HPLC), and the total content of phenols and flavonoids was determined. The hypoglycemic activity was evaluated in vivo using alloxan-induced diabetic mice. The effect upon inflammatory mediators was evaluated in vitro using the human monocytic leukemia cell line (THP-1). The anti-hypercholesterolemic activity was evaluated in vitro using the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase assay kit. The water extract (WE)-treated group showed the highest reduction in the fasting blood glucose levels (FBGL). The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
METHODS AND RESULTS:
Out of the five compounds in the CF,1beta,10beta-Epoxydesacetoxymatricarin (CP1) and leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.

1beta,10beta-Epoxydesacetoxymatricarin Description

Source:	The herbs of Achillea wilhelmsii.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phys Chem Chem Phys. 2013 Jan 21;15(3):795-802.

Intermolecular exciton coupling and vibronic effects in solid-state circular dichroism: a case study.[Pubmed: 23203006 ]

METHODS AND RESULTS:
The electronic circular dichroism (CD) spectrum of the sesquiterpenoid 1beta,10beta-Epoxydesacetoxymatricarin (1) measured in the microcrystalline solid state differs from the solution one in the appearance of a pronounced vibrational fine structure in the long-wavelength region (n-π* enone transition) and of a new moderately intense band in the π-π* region. TDDFT CD calculations were run on input structures derived from the X-ray geometry of 1 to reproduce the impact of exciton-type couplings between proximate molecules in the crystals.
CONCLUSIONS:
The vibrational structure of the CD spectrum was also reproduced for the isolated molecule by modelling the potential energy surfaces at the harmonic level and taking into account Duschinsky and Herzberg-Teller effects.

Product Name	1beta,10beta-Epoxydesacetoxymatricarin
Price:
CAS No.:	124020-39-9
Catalog No.:	CFN89005
Molecular Formula:	C₁₅H₁₈O₄
Molecular Weight:	262.30 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Achillea wilhelmsii.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-hyperlipidemic Compound Library Sesquiterpenoids Compound Library TNF-α Inhibitor Library MMP(e.g.TIMP) Inhibitor Library HMG-CoA Reductase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8124 mL	19.0621 mL	38.1243 mL	76.2486 mL	95.3107 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL	15.2497 mL	19.0621 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL	7.6249 mL	9.5311 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.525 mL	1.9062 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.7625 mL	0.9531 mL

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