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2',5,7-Trihydroxy-8-methoxyflavanone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 2',5,7-Trihydroxy-8-methoxyflavanone
Price:
CAS No.: 112408-71-6
Catalog No.: CFN99221
Molecular Formula: C16H14O6
Molecular Weight: 302.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Scutellaria baicalensis Georgi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 2',5,7-Trihydroxy-8-methoxyflavanone has cytotoxic activity.
In vitro:
Natural Product Sciences, 2006, 12(4):205-209.
Revision of structures of flavanoids from Scutellaria indica and their protein tyrosine phosphatase 1B inhibitory activity.[Reference: WebLink]

METHODS AND RESULTS:
The structures of flavonoids, 2(5)-5,7-dihydroxy-8,2′- dimethoxyflavanone (1), wogonin (2), 2(5)-2',5,7-Trihydroxy-8-methoxyflavanone (3), and 2(S)-5,2′,5′-trihydroxy-7,8- dimethoxyflavanone (4), isolated from Scutellaria indica were revised on the basis of 2D NMR spectroscopy, including to gCOSY, gHSQC, and gHMBC. Compounds 1-4 were tested in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.
CONCLUSIONS:
Compounds 2 and 4 exhibited weak PTP1B inhibitory activity with IC50 values of 208 and 337 μM, respectively.
2',5,7-Trihydroxy-8-methoxyflavanone Description
Source: The roots of Scutellaria baicalensis Georgi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.308 mL 16.5399 mL 33.0797 mL 66.1594 mL 82.6993 mL
5 mM 0.6616 mL 3.308 mL 6.6159 mL 13.2319 mL 16.5399 mL
10 mM 0.3308 mL 1.654 mL 3.308 mL 6.6159 mL 8.2699 mL
50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3232 mL 1.654 mL
100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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Praeruptorin A

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Sanguinarine

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Eupatorin

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Oxypeucedanin hydrate

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