2'-Hydroxy-4'-methylacetophenone | CAS:6921-64-8

2'-Hydroxy-4'-methylacetophenone

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2'-Hydroxy-4'-methylacetophenone Description

Source:	The roots of Angelica koreana.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Agric Food Chem. 2012 Apr 11;60(14):3606-11.

Acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from Angelicae koreana roots and structure-activity relationships of its derivatives.[Pubmed: 22429095 ]

The acaricidal activities of 2'-Hydroxy-4'-methylacetophenone derived from Angelica koreana roots and its derivatives against Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae were examined by vapor phase and contact toxicity bioassays.
METHODS AND RESULTS:
In the vapor phase toxicity bioassay, 2'-methylacetophenone (1.25 μg/cm(2)) was 8.0 times more toxic against D. farinae than benzyl benzoate (10.00 μg/cm(2)), followed by 3'-methylacetophenone (1.26 μg/cm(2)), 4'-methylacetophenone (1.29 μg/cm(2)), 2'-Hydroxy-4'-methylacetophenone (1.75 μg/cm(2)), and 2'-hydroxy-5'-methylacetophenone (1.96 μg/cm(2)). In the contact toxicity bioassay, 3'-methylacetophenone (0.58 μg/cm(2)) was 17.24 times more effective against D. farinae than benzyl benzoate (7.52 μg/cm(2)), followed by 2'-methylacetophenone (0.64 μg/cm(2)), 2'-Hydroxy-4'-methylacetophenone (0.76 μg/cm(2)), 4'-methylacetophenone (0.77 μg/cm(2)), and 2'-hydroxy-5'-methylacetophenone (1.16 μg/cm(2)). The acaricidal activities of 2'-Hydroxy-4'-methylacetophenone derivatives against D. pteronyssinus and T. putrescentiae were similar to those against D. farinae.
CONCLUSIONS:
In terms of structure-activity relationships, acaricidal activity against the three mite species changed with the introduction of hydroxyl and methyl functional groups onto the acetophenone skeleton. Furthermore, some of 2'-Hydroxy-4'-methylacetophenone derivatives could be useful for natural acaricides against three mite species.

Product Name	2'-Hydroxy-4'-methylacetophenone
Price:
CAS No.:	6921-64-8
Catalog No.:	CFN89474
Molecular Formula:	C₉H₁₀O₂
Molecular Weight:	150.17 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Angelica koreana.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Acaricidal Compound Library Phenols Compound Library Antifection Inhibitor Library

Description:	2'-Hydroxy-4'-methylacetophenone has acaricidal activity, it could be used in the preparation of 4’-methyl-2’-[(p-tolylsulfonyl) oxy] acetophenone.
Targets:	Antifection

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.6591 mL	33.2956 mL	66.5912 mL	133.1824 mL	166.478 mL
5 mM	1.3318 mL	6.6591 mL	13.3182 mL	26.6365 mL	33.2956 mL
10 mM	0.6659 mL	3.3296 mL	6.6591 mL	13.3182 mL	16.6478 mL
50 mM	0.1332 mL	0.6659 mL	1.3318 mL	2.6636 mL	3.3296 mL
100 mM	0.0666 mL	0.333 mL	0.6659 mL	1.3318 mL	1.6648 mL

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