2-(Hydroxymethyl)anthraquinone | CAS:17241-59-7

2-(Hydroxymethyl)anthraquinone

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Product Name	2-(Hydroxymethyl)anthraquinone
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CAS No.:	17241-59-7
Catalog No.:	CFN92110
Molecular Formula:	C₁₅H₁₀O₃
Molecular Weight:	238.2 g/mol
Purity:	>=98%
Type of Compound:	Anthraquinones
Physical Desc.:	Yellow powder
Source:	The dried inner bark (taheebo) of Tabebuia impetiginosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

2-(Hydroxymethyl)anthraquinone exhibits strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc.

Targets:

Antifection

In vitro:

J Ethnopharmacol. 2006 Apr 21;105(1-2):255-62.

Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori[Pubmed: 16359837]

METHODS AND RESULTS:
The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) bioassays. The activity of the isolated compounds was compared to that of the commercially available anti-Helicobacter pylori agents, amoxicillin, metronidazole, and tetracycline. The biologically active components of Tabebuia impetiginosa dried inner bark (taheebo) were characterized by spectroscopic analysis as 2-(Hydroxymethyl)anthraquinone, anthraquinone-2-carboxylic acid, and 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). With the paper disc diffusion assay 2-(Hydroxymethyl)anthraquinone exhibited strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. Anthraquinone-2-carboxylic acid, lapachol and metronidazole were less effective, exhibiting moderate anti-Helicobacter pylori activity at 0.1 mg/disc. Amoxicillin and tetracycline were the most potent compounds tested, displaying very strong activity at 0.005 mg/disc. 2-(Hydroxymethyl)anthraquinone exhibited moderate activity at this dose. Tetracycline still had strong activity at 0.001 mg/disc while amoxicillin had little activity at this dose.
CONCLUSIONS:
In the MIC bioassay, 2-(Hydroxymethyl)anthraquinone (2 μg/mL), anthraquinone-2-carboxylic acid (8 μg/mL), and lapachol (4 μg/mL) were more active than metronidazole (32 μg/mL) but less effective than amoxicillin (0.063 μg/mL) and tetracycline (0.5 μg/mL).

2-(Hydroxymethyl)anthraquinone Description

Source:	The dried inner bark (taheebo) of Tabebuia impetiginosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Anthraquinones Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1982 mL	20.9908 mL	41.9815 mL	83.9631 mL	104.9538 mL
5 mM	0.8396 mL	4.1982 mL	8.3963 mL	16.7926 mL	20.9908 mL
10 mM	0.4198 mL	2.0991 mL	4.1982 mL	8.3963 mL	10.4954 mL
50 mM	0.084 mL	0.4198 mL	0.8396 mL	1.6793 mL	2.0991 mL
100 mM	0.042 mL	0.2099 mL	0.4198 mL	0.8396 mL	1.0495 mL

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CFN92567	1-Hydroxy-2-methylanthraquinone	6268-09-3	238.2	C₁₅H₁₀O₃
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