(2R,3S)-Dihydrodehydroconiferyl alcohol | CAS:126253-41-6

(2R,3S)-Dihydrodehydroconiferyl alcohol

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Description:

(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.

Targets:

PKC | MAPK

In vitro:

Arch Pharm Res. 2005 Dec;28(12):1337-40.

Induction of neurite outgrowth by (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol from PC12 cells.[Pubmed: 16392665]

METHODS AND RESULTS:
A lignan derivative, (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol ((2R,3S)-Dihydrodehydroconiferyl alcohol,DHDA), was isolated from Kalopanax septemlobus L. and was observed to have neuritogenic activity. DHDA at 50 microM caused a marked induction of neurite outgrowth and an enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. However, it did not exhibit any neurotrophic action. At 50 microM, DHDA enhanced NGF-induced neurite-bearing activity. This activity was partially blocked by the mitogen-activated protein kinase (MAPK) inhibitor PD98059 and by GF109203X, a protein kinase C (PKC) inhibitor.
CONCLUSIONS:
These results suggest that DHDA can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.

(2R,3S)-Dihydrodehydroconiferyl alcohol Description

Source:	The barks of Eucommia ulmoides Oliver
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	(2R,3S)-Dihydrodehydroconiferyl alcohol
Price:
CAS No.:	126253-41-6
Catalog No.:	CFN92904
Molecular Formula:	C₂₀H₂₄O₆
Molecular Weight:	360.40 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The barks of Eucommia ulmoides Oliver
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library PKC Inhibitor Library MAPK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7747 mL	13.8735 mL	27.7469 mL	55.4939 mL	69.3674 mL
5 mM	0.5549 mL	2.7747 mL	5.5494 mL	11.0988 mL	13.8735 mL
10 mM	0.2775 mL	1.3873 mL	2.7747 mL	5.5494 mL	6.9367 mL
50 mM	0.0555 mL	0.2775 mL	0.5549 mL	1.1099 mL	1.3873 mL
100 mM	0.0277 mL	0.1387 mL	0.2775 mL	0.5549 mL	0.6937 mL

CFN92904	(2R,3S)-Dihydrodehydroconiferyl alcohol	126253-41-6	360.40	C₂₀H₂₄O₆
CFN98342	Dihydrodehydrodiconiferyl alcohol	28199-69-1	360.4	C₂₀H₂₄O₆
CFN96567	Dehydrodiconiferyl alcohol	4263-87-0	358.39	C₂₀H₂₂O₆
CFN89430	Dehydrodiconiferyl alcohol 4-O-beta-D-glucopyranoside	107870-88-2	520.52	C₂₆H₃₂O₁₁
CFN97556	5-O-Methylhierochin D	155836-29-6	358.4	C₂₀H₂₂O₆
CFN95586	Schisphenlignan I	1542234-14-9	400.4	C₂₂H₂₄O₇
CFN99853	Dimeric coniferyl acetate	184046-40-0	442.5	C₂₄H₂₆O₈
CFN89330	Meliasendanin D	1820034-05-6	392.40	C₂₀H₂₄O₈
CFN92720	Ceplignan	185244-78-4	346.3	C₁₈H₁₈O₇
CFN96070	Curlignan	220736-54-9	360.4	C₁₉H₂₀O₇