3,3'',5-Triiodo-L-thyronine Sodium Salt | CAS:55-06-1

3,3'',5-Triiodo-L-thyronine Sodium Salt

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Size /Price /Stock	10 mM * 1 mL in DMSO / $15.4 / In-stock
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Description:

The administration of 3,3'',5-Triiodo-L-thyronine Sodium Salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M), a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M.

Targets:

Estrogen receptor | Antifection | Progestogen receptor

In vivo:

J Vasc Res. 2014;51(5):350-9.

Vascular function of the mesenteric artery isolated from thyroid hormone receptor-α knockout mice.[Pubmed: 25500991]

This study evaluated the consequences of thyroid hormone receptor-α (TRα) disruption on vascular reactivity.
METHODS AND RESULTS:
The activity of superior mesenteric arteries isolated from TRα knockout mice generated in the SV129 background (TRα(0/0)SV) or in a pure C57BL/6 background (TRα(0/0)C57) was compared to that of their corresponding wild-type strains (SV129 or C57BL/6 mice). The wild-type SV129 mice exhibited an impaired acetylcholine (Ach)-induced mesenteric artery relaxation compared to C57BL/6 mice, associated with greater responses to angiotensin II (AII) and phenylephrine (PE). The disruption of TRα decreased the vascular response to sodium nitroprusside and PE in both the SV129 and C57BL/6 genetic backgrounds. Responses to Ach and AII were also blunted, but only in TRα(0/0)C57 mice. The administration of 3,3'',5-Triiodo-L-thyronine Sodium Salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M); a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M. However, the response to T3 was nearly absent in TRα(0/0)C57 mice.
CONCLUSIONS:
TRα is essential for the control of vascular tone, particularly in thyroid hormone-mediated relaxation. The difference in response to Ach observed between the two wild-type mice should be taken into account for interpreting the vascular responses of genetically engineered mice.

3,3'',5-Triiodo-L-thyronine Sodium Salt Description

Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3,3'',5-Triiodo-L-thyronine Sodium Salt
Price:	$30 / 20mg
CAS No.:	55-06-1
Catalog No.:	CFN90069
Molecular Formula:	C₁₅H₁₁I₃NNaO₄
Molecular Weight:	672.96 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Vasorelaxation Compound Library Alkaloids Compound Library Progestogen receptor Inhibitor Library Estrogen receptor Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.486 mL	7.4299 mL	14.8597 mL	29.7194 mL	37.1493 mL
5 mM	0.2972 mL	1.486 mL	2.9719 mL	5.9439 mL	7.4299 mL
10 mM	0.1486 mL	0.743 mL	1.486 mL	2.9719 mL	3.7149 mL
50 mM	0.0297 mL	0.1486 mL	0.2972 mL	0.5944 mL	0.743 mL
100 mM	0.0149 mL	0.0743 mL	0.1486 mL	0.2972 mL	0.3715 mL

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