3-Epicabraleahydroxylactone | CAS:35833-72-8

3-Epicabraleahydroxylactone

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Description:

3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter.

In vitro:

Chem Pharm Bull (Tokyo). 2004 Jan;52(1):153-6.

3-epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation.[Pubmed: 14709887]

METHODS AND RESULTS:
The structure of a triterpenoid isolated from the nonsaponifiable lipid (NSL) of the seed oil of the camellia (Camellia japonica L.; Theaceae) was established to be (20S)-3beta-hydroxy-25,26,27-trisnordammaran-24,20-olide (1; 3-Epicabraleahydroxylactone) on the basis of spectroscopic and chemical methods. Six other triterpenoids isolated from the NSL were identified as 3-epicabraleadiol (2), ocotillol II (3), ocotillol I (4), dammarenediol II (5), (20R)-taraxastane-3beta,20-diol (6), and lupane-3beta,20-diol (7).
CONCLUSIONS:
Upon evaluation of the seven triterpenoids (1-7) with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, three compounds (5-7) showed potent inhibitory effects against EBV-EA induction (IC(50) values of 277-420 mol ratio/32 pmol TPA).

3-Epicabraleahydroxylactone Description

Source:	The seeds of Melia azedarach.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3-Epicabraleahydroxylactone
Price:
CAS No.:	35833-72-8
Catalog No.:	CFN98482
Molecular Formula:	C₂₇H₄₄O₃
Molecular Weight:	416.6 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Melia azedarach.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4004 mL	12.0019 mL	24.0038 mL	48.0077 mL	60.0096 mL
5 mM	0.4801 mL	2.4004 mL	4.8008 mL	9.6015 mL	12.0019 mL
10 mM	0.24 mL	1.2002 mL	2.4004 mL	4.8008 mL	6.001 mL
50 mM	0.048 mL	0.24 mL	0.4801 mL	0.9602 mL	1.2002 mL
100 mM	0.024 mL	0.12 mL	0.24 mL	0.4801 mL	0.6001 mL

CFN98482	3-Epicabraleahydroxylactone	35833-72-8	416.6	C₂₇H₄₄O₃
CFN98480	Cabraleahydroxylactone	35833-69-3	416.6	C₂₇H₄₄O₃
CFN98481	Cabraleahydroxylactone acetate	35833-70-6	458.7	C₂₉H₄₆O₄
CFN98005	Cabralealactone	19865-87-3	414.6	C₂₇H₄₂O₃
CFN98092	Eichlerialactone	2202-01-9	430.6	C₂₇H₄₂O₄