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3'-O-Methylmurraol
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Product Name 3'-O-Methylmurraol
Price:
CAS No.: 1891097-17-8
Catalog No.: CFN89183
Molecular Formula: C16H18O4
Molecular Weight: 274.31 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The fruits of Cnidium monnieri.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 3'-O-Methylmurraol may have potential anti-inflammatory activity, it exhibits inhibition (IC50 ≤ 7.31 ug/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB).
Targets: Immunology & Inflammation related
In vitro:
Int J Mol Sci. 2014 May 28;15(6):9566-78.
New coumarins and anti-inflammatory constituents from the fruits of Cnidium monnieri.[Pubmed: 24879527 ]
The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases.
METHODS AND RESULTS:
Three new coumarins, 3'-O-Methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-12, and 14-17 exhibited inhibition (IC50 ≤ 7.31 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9-11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 μg/mL.
CONCLUSIONS:
This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
3'-O-Methylmurraol Description
Source: The fruits of Cnidium monnieri.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6455 mL 18.2276 mL 36.4551 mL 72.9102 mL 91.1378 mL
5 mM 0.7291 mL 3.6455 mL 7.291 mL 14.582 mL 18.2276 mL
10 mM 0.3646 mL 1.8228 mL 3.6455 mL 7.291 mL 9.1138 mL
50 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.4582 mL 1.8228 mL
100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7291 mL 0.9114 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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