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Ajugol
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Product Name Ajugol
Price: $80 / 20mg
CAS No.: 52949-83-4
Catalog No.: CFN90759
Molecular Formula: C15H24O9
Molecular Weight: 348.4 g/mol
Purity: >=98%
Type of Compound: Iridoids
Physical Desc.: Powder
Source: The roots of Rehmannia glutinosa.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $21.5 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ajugol shows some trypanocidal potential against Trypanosoma brucei rhodesiense (IC50 values 29.3–73.0 ug/ml).
Targets: Antifection
In vitro:
Phytochemistry, 2005, 66(3):355-62.
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots.[Pubmed: 15680992 ]
The ethanolic root extract of Scrophularia lepidota, an endemic plant of the Turkish flora, has been investigated for its anti-protozoal and inhibitory effect towards plasmodial enoyl-ACP reductase (FabI), a key enzyme of fatty acid biosynthesis in Plasmodium falciparum.
METHODS AND RESULTS:
Chromatographic separation of the extract yielded 10 iridoids (1-10), two of which are new, and a known phenylethanoid glycoside (11). The structures of the new compounds were determined as 3,4-dihydro-methylcatalpol (8) and 6-O-[4''-O-trans-(3,4-dimethoxycinnamoyl)-alpha-L-rhamnopyranosyl]aucubin (scrolepidoside, 9) by spectroscopic means. The remaining metabolites were characterized as catalpol (1), 6-O-methylcatalpol (2), aucubin (3), 6-O-alpha-L-rhamnopyranosyl-aucubin (sinuatol, 4), 6-O-beta-D-xylopyranosylaucubin (5), Ajugol (6), ajugoside (7), an iridoid-related aglycone (10) and angoroside C (11). Nine isolates were active against Leishmania donovani, with the new compound 9 being most potent (IC50 6.1 microg/ml). Except for 4, all pure compounds revealed some trypanocidal potential against Trypanosoma brucei rhodesiense (IC50 values 29.3-73.0 microg/ml). Only compound 10 showed moderate anti-plasmodial (IC50 40.6 microg/ml) and FabI enzyme inhibitory activity (IC50 100 microg/ml). 10 is the second natural product inhibiting the fatty acid biosynthesis of Plasmodium falciparum.
In vivo:
Cancer Lett . 2017 Sep 10;403:195-205.
Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways[Pubmed: 28645563]
Abstract Hepatocellular carcinoma (HCC) is known for high mortality and limited available treatments. Aberrant activation of the Wnt and Notch signaling pathways is critical to liver carcinogenesis and progression. Here, we identified a small molecule, bruceine D (BD), as a Notch inhibitor, using an RBP-Jκ-dependent luciferase-reporter system. BD significantly inhibited liver tumor growth and enhanced the therapeutic effects of sorafenib in various murine HCC models. Mechanistically, BD promotes proteasomal degradation of β-catenin and the depletion of its nuclear accumulation, which in turn disrupts the Wnt/β-catenin-dependent transcription of the Notch ligand Jagged1 in HCC. Our findings provide important information about a novel Wnt/Notch crosstalk inhibitor that is synergistic with sorafenib for treatment of HCC, and therefore have high clinical impact. Keywords: BD; Hepatocellular carcinoma; Jagged1; Sorafenib; Wnt/Notch crosstalk; β-catenin.
Ajugol Description
Source: The roots of Rehmannia glutinosa.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8703 mL 14.3513 mL 28.7026 mL 57.4053 mL 71.7566 mL
5 mM 0.5741 mL 2.8703 mL 5.7405 mL 11.4811 mL 14.3513 mL
10 mM 0.287 mL 1.4351 mL 2.8703 mL 5.7405 mL 7.1757 mL
50 mM 0.0574 mL 0.287 mL 0.5741 mL 1.1481 mL 1.4351 mL
100 mM 0.0287 mL 0.1435 mL 0.287 mL 0.5741 mL 0.7176 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Volume 23, Issue 11, 1982, Pages 1215-1216
Structural revision of ajugol and myoporoside[Reference: WebLink]

METHODS AND RESULTS:
An analysis of existing 13C NMR data shows that the structures reported for the iridoid glucosides Ajugol and myoporoside should be interchanged.
CONCLUSIONS:
Consequently, the structures of ajugoside and laterioside, both acyl-derivatives of Ajugol, as well as that of 8-O-acetyl-myoporoside need revision.
Taurocholic acid

Catalog No: CFN96646
CAS No: 81-24-3
Price: $ / mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Octahydrocurcumin

Catalog No: CFN90584
CAS No: 36062-07-4
Price: $388/20mg
Geniposidic acid

Catalog No: CFN98337
CAS No: 27741-01-1
Price: $30/20mg
Fraxidin

Catalog No: CFN98860
CAS No: 525-21-3
Price: $268/10mg
Atractylodin

Catalog No: CFN99535
CAS No: 55290-63-6
Price: $60/20mg
Cimifugin

Catalog No: CFN98612
CAS No: 37921-38-3
Price: $60/20mg
Pseudoprotodioscin

Catalog No: CFN90694
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Price: $138/20mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Cheilanthifoline

Catalog No: CFN90945
CAS No: 483-44-3
Price: $318/10mg
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