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- Product Intended Use
- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
4',5,6,7-Tetramethoxyflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
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Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $134.3 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
- Phytother Res.2022, 35844057.
- University of Limpopo2016, 1-237
- Institute of Food Science & Techn...2021...
- Front Cell Infect Microbiol.2018, 8:292
- Front Pharmacol.2018, 9:756
- Pharmaceuticals (Basel)....2022...
- Nutrients.2021, 13(3):978.
- Asian Pac J Cancer Prev....2019...
- JEJU National University2022, 24032.
- Front Pharmacol.2016, 7:460
- Comparative Clinical Pathology ...2021...
- J. of The Korean Society of Food ...2017...
- Phytomedicine.2020, 79, 153351
- BMC Complement Altern Med....2017...
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- FASEB J.2019, 33(8):9685-9694
- Sains Malaysiana2022, 51(4):1143-1154
- Neuropharmacology.2018, 131:68-82
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- Eur J Pharmacol.2020, 889:173589.
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Our products had been exported to the following research institutions and universities, And still growing.
- University of Amsterdam (Netherlands)
- Instytut Nawozów Sztucznych w ... (Poland)
- Imperial College London (United Kingdom)
- Lodz University of Technology (Poland)
- University of Auckland (New Zealand)
- Griffith University (Australia)
- University of Malaya (Malaysia)
- Yale University (USA)
- University of Perugia (Italy)
- Medical University of South Car... (USA)
- Srinakharinwirot University (Thailand)
- More...
- Phytochemistry2018, 15:83-92
- J. of Med. Plant Research.2013, 90-151
- Int J Mol Sci.2020, 21(24):9369.
- Front Pharmacol.2019, 10:1025
- J. of The Korean Society of Food Culture2017, 144-149
- Int J Nanomedicine.2022, 17:6513-6525.
- Iranian J. Pharm. Res.2021, 20(4):59-70
- Heliyon.2023, e12778.
- Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
- Exp Parasitol.2015, 153:160-4
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
4',5,6,7-Tetramethoxyflavone has a hemostatic effect. |
| Targets: |
PAFR |
| In vitro: |
| Molecules. 2011 Jun 10;16(6):4828-35. | | Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance.[Pubmed: 21666549] |
METHODS AND RESULTS:
Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4'-dimethylapigenin, trimethylapigenin, cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance.
CONCLUSIONS:
This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4',5,6,7-Tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold. | | J Med Assoc Thai. 1991 May;74(5):283-7. | | Effect of Eupatorium odoratum on blood coagulation.[Pubmed: 1783877] |
METHODS AND RESULTS:
The purified compound, 4',5,6,7-Tetramethoxyflavone, is an active ingredient isolated from Eupatorium odoratum, a Thai indigenous plant that has long been used to stop bleeding. This compound was studied in vitro for the effect on blood clotting factor activities. It was found that the compound enhanced blood coagulation, the observed APTT being shorter than that observed in the control.
CONCLUSIONS:
The result suggested that the compound accelerated clotting time through the intrinsic pathway of the coagulation which may involve the reaction of factor XII, factor XI, factor IX or factor VIII. |
|
4',5,6,7-Tetramethoxyflavone Description
| Source: |
The roots of Scutellaria baicalensis |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.9206 mL |
14.6028 mL |
29.2056 mL |
58.4112 mL |
73.014 mL |
| 5 mM |
0.5841 mL |
2.9206 mL |
5.8411 mL |
11.6822 mL |
14.6028 mL |
| 10 mM |
0.2921 mL |
1.4603 mL |
2.9206 mL |
5.8411 mL |
7.3014 mL |
| 50 mM |
0.0584 mL |
0.2921 mL |
0.5841 mL |
1.1682 mL |
1.4603 mL |
| 100 mM |
0.0292 mL |
0.146 mL |
0.2921 mL |
0.5841 mL |
0.7301 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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