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5,7-Dimethoxyflavanone
5,7-Dimethoxyflavanone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 5,7-Dimethoxyflavanone
Price:
CAS No.: 1036-72-2
Catalog No.: CFN92662
Molecular Formula: C17H16O4
Molecular Weight: 284.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Cryst.
Source: The stem barks of Uvaria mocoli
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Biological Activity
Description: 5,7-Dimethoxyflavanone has anti-inflammatory activities.
Targets: TNF-α | NO | IL Receptor | IFN-γ
In vitro:
J Ethnopharmacol. 2005 Sep 14;100(3):249-53.
Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima.[Pubmed: 15893896]

METHODS AND RESULTS:
The anti-inflammatory activities of five flavonoids, namely 5,7-Dimethoxyflavanone (1), 5,7-dimethoxy-3',4'-methylenedioxyflavanone (2), isobonducellin (3), 2'-hydroxy-2,3,4',6'-tetramethoxychalcone (4) and bonducellin (5), all of them isolated from Caesalpinia pulcherrima L. was studied in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages. These five compounds significantly and dose-dependently inhibited the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. According to their inhibitory results, the order of anti-inflammatory potency was compounds 3>5>4>2>1. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-gamma for 24h, and determined the inhibitory effects of the above-mentioned isolates on the production of NO after a further 24h.
CONCLUSIONS:
The present study supports the use of Caesalpinia pulcherrima for the treatment of inflammatory diseases in traditional medicine. This is the first study on compounds 1-5 about their anti-inflammatory activities.
5,7-Dimethoxyflavanone Description
Source: The stem barks of Uvaria mocoli
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5174 mL 17.5871 mL 35.1741 mL 70.3482 mL 87.9353 mL
5 mM 0.7035 mL 3.5174 mL 7.0348 mL 14.0696 mL 17.5871 mL
10 mM 0.3517 mL 1.7587 mL 3.5174 mL 7.0348 mL 8.7935 mL
50 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.407 mL 1.7587 mL
100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7035 mL 0.8794 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry.1998 Apr;47(7):1387–1391.
A novel retrodihydrochalcone from the stem bark of Uvaria mocoli.[Reference: WebLink]

METHODS AND RESULTS:
Investigation of the ethyl acetate extract of the stem bark of Uvaria mocoli resulted in the isolation of the novel retrodihydrochalcone 2-hydroxy-4,5,6-trimethoxydihydrochalcone together with the known flavonoids 2′-hydroxy-4′,6′-dimethoxychalcone, 2′-hydroxy-4′,5′,6′-trimethoxychalcone, 5,7-Dimethoxyflavanone and 5,7,8-trimethoxyflavanone, the oxoaporphines lysicamine, liriodenine and isomoschatoline, benzoic acid and a mixture of sitosterol and stigmasterol. All the compounds were identified by analysis of their spectral data.
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