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5-Hydroxy-2-pyrrolidinone
5-Hydroxy-2-pyrrolidinone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 5-Hydroxy-2-pyrrolidinone
Price:
CAS No.: 62312-55-4
Catalog No.: CFN97072
Molecular Formula: C4H7NO2
Molecular Weight: 101.1 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Buddleja asiatica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Standard reference
5-Hydroxy-2-pyrrolidinone Description
Source: The herbs of Buddleja asiatica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 9.8912 mL 49.456 mL 98.912 mL 197.8239 mL 247.2799 mL
5 mM 1.9782 mL 9.8912 mL 19.7824 mL 39.5648 mL 49.456 mL
10 mM 0.9891 mL 4.9456 mL 9.8912 mL 19.7824 mL 24.728 mL
50 mM 0.1978 mL 0.9891 mL 1.9782 mL 3.9565 mL 4.9456 mL
100 mM 0.0989 mL 0.4946 mL 0.9891 mL 1.9782 mL 2.4728 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Life Sci. 1984 Nov 26;35(22):2205-12.
2-Pyrrolidinone and succinimide endogenously present in several mammalian species.[Pubmed: 6503611]

METHODS AND RESULTS:
2-Pyrrolidinone and succinimide were identified in blood plasma of man, rat, and mouse. Dog plasma contained only traces of 2-pyrrolidinone not exceeding significantly the detection limit of our GCMS-method. Succinimide but not 2-pyrrolidinone could also be found in the brains of rat and mouse.
CONCLUSIONS:
Evidence is presented for a metabolic pathway leading from 2-pyrrolidinone to succinimide, with 5-Hydroxy-2-pyrrolidinone as an intermediate.
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