| Animal Research: |
| Fundam Clin Pharmacol. 2011 Jun;25(3):362-7. | | Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system.[Pubmed: 20608992] | Carvacrol (5-Isopropyl-2-methylphenol) is a monoterpenic phenol present in the essential oil of many plants. It is the major component of the essential oil fraction of oregano and thyme.
METHODS AND RESULTS:
In this study, the effect of carvacrol was investigated in two behavioral models, the forced swimming and tail suspension tests in mice, to investigate the possible antidepressant effect of this substance. Additionally, the mechanisms involved in the antidepressant-like effect of 5-Isopropyl-2-methylphenol in mice were also assessed. 5-Isopropyl-2-methylphenol (cvc) was administered orally at single doses of 12.5, 25 and 50 mg/kg. The acute treatment of cvc decreased the immobility time in the forced swimming and tail suspension tests without accompanying changes in ambulation in the open-field test. The anti-immobility effect of 5-Isopropyl-2-methylphenol (25 mg/kg) was not prevented by pretreatment of mice with p-chlorophenylalanine, prazosin and yohimbine. On the other hand, the pretreatment of mice with SCH23390 or sulpiride completely blocked the antidepressant-like effect of 5-Isopropyl-2-methylphenol (25 mg/kg) in the forced swimming test.
CONCLUSIONS:
These results show that 5-Isopropyl-2-methylphenol presents antidepressant effects in the forced swimming and tail suspension tests; this effect seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems. | | Fundam Clin Pharmacol. 2010 Aug;24(4):437-43. | | Anxiolytic-like effect of Carvacrol (5-isopropyl-2-methylphenol) in mice: involvement with GABAergic transmission.[Pubmed: 19909350] | Carvacrol (5-Isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme.
METHODS AND RESULTS:
This work presents the behavioral effects of 5-Isopropyl-2-methylphenol in animal models of elevated plus maze (EPM), open field, Rotarod and barbiturate-induced sleeping time tests in mice. 5-Isopropyl-2-methylphenol (CVC) was administered orally, in male mice, at single doses of 12.5; 25 and 50 mg/kg while diazepam 1 or 2 mg/kg was used as standard drug and flumazenil (2.5 mg/kg) was used to elucidate the possible anxiolytic mechanism of 5-Isopropyl-2-methylphenol on the plus maze test. The results showed that 5-Isopropyl-2-methylphenol, at three doses, had no effect on the spontaneous motor activity in the Rotarod test nor in the number of squares crossed in the open-field test. However, 5-Isopropyl-2-methylphenol decreased the number of groomings in the open-field test. In the plus maze test, 5-Isopropyl-2-methylphenol, at three doses significantly increased all the observed parameters in the EPM test and flumazenil was able to reverse the effects of diazepam and 5-Isopropyl-2-methylphenol. Therefore, 5-Isopropyl-2-methylphenol did not alter the sleep latency and sleeping time in the barbiturate-induced sleeping time test.
CONCLUSIONS:
These results show that 5-Isopropyl-2-methylphenol presents anxiolytic effects in the plus maze test which are not influenced by the locomotor activity in the open-field test. |
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