7,3',4'-Trihydroxyflavone | CAS:2150-11-0

7,3',4'-Trihydroxyflavone

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Product Name	7,3',4'-Trihydroxyflavone
Price:	$118 / 20mg
CAS No.:	2150-11-0
Catalog No.:	CFN97786
Molecular Formula:	C₁₅H₁₀O₅
Molecular Weight:	270.24 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The seeds of Cassia occidentalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $34.9 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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7,3',4'-Trihydroxyflavone Description

Source:	The seeds of Cassia occidentalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Pharmazie, 2015, 70(10):661-7.

3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1.[Pubmed: 26601423]

3'4'7-Trihydroxyflavone(7,3',4'-Trihydroxyflavone) is a flavonoid from ladino clover, alfalfa, and Albizzia julibrissin .
METHODS AND RESULTS:
In the present study, we found that 3'4'7-trihydroxyflavone markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs). 3'4'7-trihydroxyflavone also reduced the mRNA expression level of osteoclastic marker genes including calcitonin receptor (CTR), Cathepsin K, v-ATPase V0 subunit d2 (ATP6v0d2), and dendritic cell-specific transmembrane protein (DC-STAMP). In addition, 3'4'7-trihydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3'4'7-trihydroxyflavone inhibited RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, 3'4'7-trihydroxyflavone attenuated RANKL-induced activation of p38 mitogenactivated protein kinase (MAPK) and expression of B lymphocyte-induced maturation protein 1 (Blimp1), a repressor of negative regulators of NFATc1.
CONCLUSIONS:
Taken together, our data suggest that 3'4'7-trihydroxyflavone inhibits osteoclastogenesis NFATc1.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-osteoclastogenesis Compound Library Flavonoids Compound Library p38MAPK Inhibitor Library NF-kB Inhibitor Library ATPase Inhibitor Library

Description:	3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1).
Targets:	p38MAPK \| NF-kB \| ATPase \| RANKL

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7004 mL	18.5021 mL	37.0041 mL	74.0083 mL	92.5104 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL	14.8017 mL	18.5021 mL
10 mM	0.37 mL	1.8502 mL	3.7004 mL	7.4008 mL	9.251 mL
50 mM	0.074 mL	0.37 mL	0.7401 mL	1.4802 mL	1.8502 mL
100 mM	0.037 mL	0.185 mL	0.37 mL	0.7401 mL	0.9251 mL

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