7-Ethoxycoumarin | CAS:31005-02-4 | Manufacturer ChemFaces

7-Ethoxycoumarin

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7-Ethoxycoumarin Description

Source:	The herbs of Citrus reticulata cv. Chachiensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Drug Metab Dispos. 2008 Nov;36(11):2166-70.

Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.[Pubmed: 18669587]

Recently, wild-type and mutant forms of bacterial cytochrome P450 BM3 (CYP102A1) have been found to metabolize various drugs through reactions similar to those catalyzed by human cytochromes P450 (P450s). Therefore, it has been suggested that CYP102A1 may be used to produce large quantities of the metabolites of human P450-catalyzed reactions.
METHODS AND RESULTS:
In this report, we show that the oxidation of 7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1. Two major products were produced as a result of O-deethylation and 3-hydroxylation reactions. These results demonstrate that CYP102A1 mutants catalyze the same reactions as human P450s. High noncompetitive intermolecular kinetic deuterium isotope effects were observed for 7-Ethoxycoumarin O-deethylation in the CYP102A1 system.
CONCLUSIONS:
These results suggest that there is a common mechanism for the oxidation reactions catalyzed by both the bacterial CYP102A1 and human P450 enzymes.

Product Name	7-Ethoxycoumarin
Price:	$30 / 20mg
CAS No.:	31005-02-4
Catalog No.:	CFN90567
Molecular Formula:	C₁₁H₁₀O₃
Molecular Weight:	190.2 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Cryst.
Source:	The herbs of Citrus reticulata cv. Chachiensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library P450 (e.g. CYP17) Inhibitor Library

Description:	The oxidation of 7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.
Targets:	P450 (e.g. CYP17)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.2576 mL	26.2881 mL	52.5762 mL	105.1525 mL	131.4406 mL
5 mM	1.0515 mL	5.2576 mL	10.5152 mL	21.0305 mL	26.2881 mL
10 mM	0.5258 mL	2.6288 mL	5.2576 mL	10.5152 mL	13.1441 mL
50 mM	0.1052 mL	0.5258 mL	1.0515 mL	2.103 mL	2.6288 mL
100 mM	0.0526 mL	0.2629 mL	0.5258 mL	1.0515 mL	1.3144 mL

CFN99552	Coumarin	91-64-5	146.15	C₉H₆O₂
CFN96597	6-Methylcoumarin	92-48-8	160.17	C₁₀H₈O₂
CFN91113	7-Methylcoumarin	2445-83-2	160.17	C₁₀H₈O₂
CFN97503	Umbelliferone	93-35-6	162.1	C₉H₆O₃
CFN90566	7-Methoxycoumarin	531-59-9	176.2	C₁₀H₈O₃
CFN90567	7-Ethoxycoumarin	31005-02-4	190.2	C₁₁H₁₀O₃
CFN90419	4-Hydroxycoumarin	1076-38-6	162.14	C₉H₆O₃
CFN94403	4-Methoxycoumarine	20280-81-3	176.17	C₁₀H₈O₃
CFN97505	Skimmin	93-39-0	324.3	C₁₅H₁₆O₈
CFN90311	Apiosylskimmin	103529-94-8	456.40	C₂₀H₂₄O₁₂