10-Methoxycamptothecin | CAS:19685-10-0

10-Methoxycamptothecin

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Description:

10-Methoxycamptothecin possesses high anti-cancer activity.

In vivo:

Drug Res (Stuttg). 2015 Mar;65(3):147-52.

A simple HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat liver tissue.[Pubmed: 24782285]

A simple HPLC method to determine the amount of 10-Methoxycamptothecin (MCPT) and its major metabolite 10-hydroxycamptothecin (HCPT) in rat liver tissue was developed in the present study.
METHODS AND RESULTS:
Camptothecin (CPT) was used as internal standard (IS). A piecewise linear function was used over lower and higher concentrations, respectively. The calibration curves were linear (r (2) >0.99) over concentrations from 2.5 to 20 ng/mL and 20 to 320 ng/mL for both MCPT and HCPT. The method had an accuracy of 92.74% to 112.76%, and the intra- and inter-day precision (RSD%) were 11.85% or less for MCPT and HCPT. The stability data showed no significant degradation occurred under the experimental conditions.
CONCLUSIONS:
This method was successfully applied to the tissue distribution study of MCPT and its metabolite HCPT in liver tissue samples after intravenous administration.

10-Methoxycamptothecin Description

Source:	The barks of Camptotheca acuminata Decne
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	10-Methoxycamptothecin
Price:
CAS No.:	19685-10-0
Catalog No.:	CFN90157
Molecular Formula:	C₂₁H₁₈N₂O₅
Molecular Weight:	378.38 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The barks of Camptotheca acuminata Decne
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6428 mL	13.2142 mL	26.4285 mL	52.8569 mL	66.0711 mL
5 mM	0.5286 mL	2.6428 mL	5.2857 mL	10.5714 mL	13.2142 mL
10 mM	0.2643 mL	1.3214 mL	2.6428 mL	5.2857 mL	6.6071 mL
50 mM	0.0529 mL	0.2643 mL	0.5286 mL	1.0571 mL	1.3214 mL
100 mM	0.0264 mL	0.1321 mL	0.2643 mL	0.5286 mL	0.6607 mL

CFN90886	Irinotecan hydrochloride	100286-90-6	623.2	C₃₃H₃₉ClN₄O₆
CFN90336	7-Ethylcamptothecin	78287-27-1	376.41	C₂₂H₂₀N₂O₄
CFN90335	7-Ethyl-10-Hydroxycamptothecin	86639-52-3	392.4	C₂₂H₂₀N₂O₅
CFN99729	9-Methoxycamptothecine	39026-92-1	378.38	C₂₁H₁₈N₂O₅
CFN90309	9-Aminocamptothecin	91421-43-1	363.37	C₂₀H₁₇N₃O₄
CFN99735	(S)-10-Hydroxycamptothecin	19685-09-7	364.35	C₂₀H₁₆N₂O₅
CFN90157	10-Methoxycamptothecin	19685-10-0	378.38	C₂₁H₁₈N₂O₅
CFN93013	Rubitecan	91421-42-0	393.35	C₂₀H₁₅N₃O₆
CFN90439	10-Nitro-camptothecin	104195-61-1	393.34	C₂₀H₁₅N₃O₆
CFN90462	Topotecan hydrochloride	119413-54-6	457.9	C₂₃H₂₄ClN₃O₅