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10-Methoxycamptothecin
10-Methoxycamptothecin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 10-Methoxycamptothecin
Price:
CAS No.: 19685-10-0
Catalog No.: CFN90157
Molecular Formula: C21H18N2O5
Molecular Weight: 378.38 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Cryst.
Source: The barks of Camptotheca acuminata Decne
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 10-Methoxycamptothecin possesses high anti-cancer activity.
In vivo:
Drug Res (Stuttg). 2015 Mar;65(3):147-52.
A simple HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat liver tissue.[Pubmed: 24782285]
A simple HPLC method to determine the amount of 10-Methoxycamptothecin (MCPT) and its major metabolite 10-hydroxycamptothecin (HCPT) in rat liver tissue was developed in the present study.
METHODS AND RESULTS:
Camptothecin (CPT) was used as internal standard (IS). A piecewise linear function was used over lower and higher concentrations, respectively. The calibration curves were linear (r (2) >0.99) over concentrations from 2.5 to 20 ng/mL and 20 to 320 ng/mL for both MCPT and HCPT. The method had an accuracy of 92.74% to 112.76%, and the intra- and inter-day precision (RSD%) were 11.85% or less for MCPT and HCPT. The stability data showed no significant degradation occurred under the experimental conditions.
CONCLUSIONS:
This method was successfully applied to the tissue distribution study of MCPT and its metabolite HCPT in liver tissue samples after intravenous administration.
10-Methoxycamptothecin Description
Source: The barks of Camptotheca acuminata Decne
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6428 mL 13.2142 mL 26.4285 mL 52.8569 mL 66.0711 mL
5 mM 0.5286 mL 2.6428 mL 5.2857 mL 10.5714 mL 13.2142 mL
10 mM 0.2643 mL 1.3214 mL 2.6428 mL 5.2857 mL 6.6071 mL
50 mM 0.0529 mL 0.2643 mL 0.5286 mL 1.0571 mL 1.3214 mL
100 mM 0.0264 mL 0.1321 mL 0.2643 mL 0.5286 mL 0.6607 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN997299-Methoxycamptothecine39026-92-1378.38C21H18N2O5
CFN903099-Aminocamptothecin91421-43-1363.37C20H17N3O4
CFN99735(S)-10-Hydroxycamptothecin19685-09-7364.35C20H16N2O5
CFN9015710-Methoxycamptothecin19685-10-0378.38C21H18N2O5
CFN93013Rubitecan91421-42-0393.35C20H15N3O6
CFN9043910-Nitro-camptothecin104195-61-1393.34C20H15N3O6
CFN90462Topotecan hydrochloride119413-54-6457.9C23H24ClN3O5
CFN90886Irinotecan hydrochloride100286-90-6623.2C33H39ClN4O6
CFN903367-Ethylcamptothecin78287-27-1376.41C22H20N2O4
CFN903357-Ethyl-10-Hydroxycamptothecin86639-52-3392.4C22H20N2O5
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