ar-Curcumene | CAS:4176-06-1 | Manufacturer ChemFaces

ar-Curcumene

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Description:

ar-Curcumene has antiinflammatory activity, it could be used as antiinflammatory drugs in respiratory infections. ar-Curcumene is effective as oviposition deterrents against Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus, it can be considered for the development of novel and effective mosquito larvicides.

Targets:

TNF-α | IL Receptor

In vitro:

Ecotoxicol Environ Saf. 2017 Mar;137:149-157.

Toxicity of ar-curcumene and epi-β-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors[Pubmed: 27918946]

Mosquitoes act as vectors of key pathogens and parasites. Plant essential oils have been recognized as important sources of biopesticides, which do not induce resistance and have limited toxic effects on human health and non-target organisms.
METHODS AND RESULTS:
In this research, we evaluated the larvicidal and oviposition deterrence activity of Hedychium larsenii essential oil (EO) and its major compounds ar-Curcumene and epi-β-bisabolol. Both molecules showed high toxicity against early third instars of Anopheles stephensi (LC 50 =10.45 and 14.680208g/ml), Aedes aegypti (LC 50 =11.24 and 15.830208g/ml) and Culex quinquefasciatus (LC 50 =12.24 and 17.270208g/ml). In addition, low doses of ar-Curcumene and epi-β-bisabolol were effective as oviposition deterrents against the three tested mosquito species. Notably, the acute toxicity of H. larsenii oil and its major compounds against the mosquito biocontrol agent Poecilia reticulata was low, with LC 50 higher than 150002ppm.
CONCLUSIONS:
Overall, the results from this study revealed that ar-Curcumene and epi-β-bisabolol from the H. larsenii oil can be considered for the development of novel and effective mosquito larvicides.

Nat Prod Res. 2016 Oct;30(19):2225-9.

Essential oil composition, antioxidant activity and phenolic content of endemic Teucrium alyssifolium Staph. (Lamiaceae).[Pubmed: 26918276]

The present study was designed to examine the chemical composition of the essential oil, in vitro antioxidant activity and total phenolic and flavonoid content of extracts from plant parts (leaf, flower and stem) of Teucrium alyssifolium.
METHODS AND RESULTS:
The principle components of the essential oil were trans-β-caryophyllene (16.87%), ar-Curcumene (11.43%) and bisabolene (11.06%), representing 39.36% of the oil. The total phenolic contents ranged between 13.99 and 41.54 mg of GAE/g of extract. The concentrations of flavonoids varied from 16.82 to 49.52 mg of Ru/g of extract. Antioxidant activity was determined in vitro using DPPH reagent and expressed as concentration of each extract required to inhibit radical by 50% (IC50) values that ranged from 13.52 to 132.55 μg/ml.
CONCLUSIONS:
Our results have indicated that water extract of T. alyssifolium (part leaf) with a total content of polyphenols (41.54 mg of GAE/g) and an IC50 of 13.52 μg/ml is more antioxidant.

ar-Curcumene Description

Source:	The essential oil of Hedychium larsenii.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Phytother Res. 2012 Mar;26(3):333-6.

Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells.[Pubmed: 21698672 ]

The proinflammatory chemokine interleukin-8 is increased in asthmatic patients. Traditionally, ginger is used as an antiinflammatory drug.
METHODS AND RESULTS:
An extract and several compounds of Zingiber officinale (ginger) were tested in human bronchial epithelial cells (BEAS-2B cells) with respect to their effect on lipopolysaccharide (LPS)-induced secretion of the proinflammatory chemokine interleukin 8 (IL-8) and RANTES (regulated upon activation, normal T-cell expressed and secreted). An oily extract of ginger rhizome with > 25% total pungent compounds, ginger volatile oil, ar-Curcumene and α-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and β-phellandrene showed no effect. The LPS-induced slight increase of RANTES was reduced by volatile oil, ar-Curcumene and α-pinene. There was no effect of LPS on TNF-α.
CONCLUSIONS:
Our results suggest that distinct ginger compounds could be used as antiinflammatory drugs in respiratory infections.

Product Name	ar-Curcumene
Price:
CAS No.:	4176-06-1
Catalog No.:	CFN89251
Molecular Formula:	C₁₅H₂₂
Molecular Weight:	202.34 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Liquid
Source:	The essential oil of Hedychium larsenii.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library TNF-α Inhibitor Library IL Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.9422 mL	24.7109 mL	49.4218 mL	98.8435 mL	123.5544 mL
5 mM	0.9884 mL	4.9422 mL	9.8844 mL	19.7687 mL	24.7109 mL
10 mM	0.4942 mL	2.4711 mL	4.9422 mL	9.8844 mL	12.3554 mL
50 mM	0.0988 mL	0.4942 mL	0.9884 mL	1.9769 mL	2.4711 mL
100 mM	0.0494 mL	0.2471 mL	0.4942 mL	0.9884 mL	1.2355 mL

CFN91876	Bisabolangelone	30557-81-4	248.32	C₁₅H₂₀O₃
CFN89267	3,4-Seco-3-oxobisabol-10-ene-4,1-olide	1564265-85-5	252.35	C₁₅H₂₄O₃
CFN99670	Catalpalactone	1585-68-8	258.3	C₁₅H₁₄O₄
CFN99782	Fraxinellone	28808-62-0	232.28	C₁₄H₁₆O₃
CFN96832	Dasycarpol	202343-57-5	248.27	C₁₄H₁₆O₄
CFN95485	6-Methoxyfraxinellone	N/A	262.3	C₁₅H₁₈O₄
CFN96453	Vibralactone K	1623786-66-2	210.27	C₁₂H₁₈O₃
CFN96455	Vibralactone B	1093230-95-5	224.26	C₁₂H₁₆O₄
CFN96454	Vibralactone D	1251748-32-9	210.27	C₁₂H₁₈O₃
CFN96946	2-Methyl-6-(p-tolyl)heptane-2,3-diol	117421-22-4	236.35	C₁₅H₂₄O₂