Agnuside | CAS:11027-63-7 | Manufacturer ChemFaces

Agnuside

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $58.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Agnuside has anti-arthritic activity, it also shows inhibition of vascular permeability and leukocyte migration in vivo.It inhibited an array of pro-inflammatory mediators (PGE(2) and LTB(4)) and T-cell-mediated cytokines (IL-2, TNF-α, IFN-γ, IL-4, IL-10, IL-17).

Targets:

TNF-α | PGE | LTB | IL Receptor | IFN-γ

In vivo:

Inflamm Res. 2012 Apr;61(4):293-304.

Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines.[Pubmed: 22228102]

The purpose of this study was to elucidate the probable mechanism for the anti-arthritic activity of Agnuside (AGN), a compound isolated from the leaf extract of Vitex negundo.
METHODS AND RESULTS:
The anti-inflammatory activity of AGN within a dose range of 1.56-12.50 mg/kg in normal and adrenalectomized rats was evaluated against different inflammagens. An array of pro-inflammatory mediators (PGE(2) and LTB(4)) and T-cell-mediated cytokines (IL-2, TNF-α, IFN-γ, IL-4, IL-10, IL-17) was assayed using flow cytometry, in arthritic paw tissue homogenate and splenocytes of treated animals. Significant anti-arthritic activity was observed in the polyarthritis test in rats and this was associated with significant suppression of inflammatory mediators and T-cell-mediated cytokines (Th1/Th2). The anti-inflammatory activity in adrenalectomized rats confirmed that the effect of AGN is not mediated by the pituitary-adrenal axis. AGN also showed inhibition of vascular permeability and leukocyte migration in vivo.
CONCLUSIONS:
The study suggests the possible development of AGN as a therapeutic agent in the treatment of arthritis by the modulation of the host immune response.

Agnuside Description

Source:	The herbs of Vitex negundo L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Agnuside
Price:	$168 / 20mg
CAS No.:	11027-63-7
Catalog No.:	CFN99203
Molecular Formula:	C₂₂H₂₆O₁₁
Molecular Weight:	466.4 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The herbs of Vitex negundo L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Cytotoxic Compound Library Anti-arthritic Compound Library Iridoids Compound Library TNF-α Inhibitor Library PGE Inhibitor Library IL Receptor Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1441 mL	10.7204 mL	21.4408 mL	42.8816 mL	53.6021 mL
5 mM	0.4288 mL	2.1441 mL	4.2882 mL	8.5763 mL	10.7204 mL
10 mM	0.2144 mL	1.072 mL	2.1441 mL	4.2882 mL	5.3602 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	0.8576 mL	1.072 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	0.4288 mL	0.536 mL

CFN98530	Aucubin	479-98-1	346.33	C₁₅H₂₂O₉
CFN99031	6-O-p-Hydroxybenzoylaucubin	1016987-87-3	466.4	C₂₂H₂₆O₁₁
CFN99203	Agnuside	11027-63-7	466.4	C₂₂H₂₆O₁₁
CFN99891	10-O-Vanilloylaucubin	193969-08-3	496.5	C₂₃H₂₈O₁₂
CFN93097	Melittoside	19467-03-9	524.47	C₂₁H₃₂O₁₅
CFN90216	Rhmannioside D	81720-08-3	686.61	C₂₇H₄₂O₂₀