Science | Nature | Cell | View More
Natural Products
Ajmaline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ajmaline
Price:
CAS No.: 4360-12-7
Catalog No.: CFN93513
Molecular Formula: C20H26N2O2
Molecular Weight: 326.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Rauvolfia verticillata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Florida A&M University (USA)
  • University of Virginia (USA)
  • Sanford Burnham Medical Researc... (USA)
  • Ain Shams University (Egypt)
  • Amity University (India)
  • The Institute of Cancer Research (United Kingdom)
  • The Australian National University (Australia)
  • Georgia Institute of Technology (USA)
  • Semmelweis Unicersity (Hungary)
  • Universidad Veracuzana (Mexico)
  • CSIRO - Agriculture Flagship (Australia)
  • More...
Package
Featured Products
Daidzin 6''-O-malonate

Catalog No: CFN91028
CAS No: 124590-31-4
Price: $318/5mg
Pinoresinol 4-O-beta-D-glucopyrano...

Catalog No: CFN97180
CAS No: 69251-96-3
Price: $100/20mg
Glycyrrhizic acid ammonium salt

Catalog No: CFN99153
CAS No: 53956-04-0
Price: $40/20mg
beta-Eudesmol

Catalog No: CFN99537
CAS No: 473-15-4
Price: $288/20mg
Aloenin A

Catalog No: CFN93235
CAS No: 38412-46-3
Price: $ / mg
Gastrodin

Catalog No: CFN99549
CAS No: 62499-27-8
Price: $30/20mg
Liquiritin apioside

Catalog No: CFN90707
CAS No: 74639-14-8
Price: $90/20mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
Astrasieversianin VII

Catalog No: CFN90648
CAS No: 86764-11-6
Price: $238/10mg
DL-Syringaresinol

Catalog No: CFN99276
CAS No: 1177-14-6
Price: $ /
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations.
Targets: Potassium Channel
Ajmaline Description
Source: The roots of Rauvolfia verticillata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Ganoderic acid GS-3

Catalog No: CFN95518
CAS No: 1206781-66-9
Price: $413/5mg
(Z)-Ferulic acid 4-O-beta-D-glucos...

Catalog No: CFN95546
CAS No: 94942-20-8
Price: $318/10mg
Sibiricose A4

Catalog No: CFN95298
CAS No: 241125-73-5
Price: $318/5mg
Herbacetin 3-sophoroside-8-glucosi...

Catalog No: CFN95529
CAS No: 77298-68-1
Price: $318/5mg
Methyl ganoderenate D

Catalog No: CFN95572
CAS No: 748136-03-0
Price: $413/5mg
Cannabisin A

Catalog No: CFN95287
CAS No: 130508-46-2
Price: $318/5mg
Lyciumamide B

Catalog No: CFN95286
CAS No: 1647111-41-8
Price: $318/5mg
Catechin 7-O-beta-D-glucopyranosid...

Catalog No: CFN95524
CAS No: 65597-47-9
Price: $338/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0637 mL 15.3186 mL 30.6373 mL 61.2745 mL 76.5931 mL
5 mM 0.6127 mL 3.0637 mL 6.1275 mL 12.2549 mL 15.3186 mL
10 mM 0.3064 mL 1.5319 mL 3.0637 mL 6.1275 mL 7.6593 mL
50 mM 0.0613 mL 0.3064 mL 0.6127 mL 1.2255 mL 1.5319 mL
100 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6127 mL 0.7659 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Naunyn Schmiedebergs Arch Pharmacol. 2013 Nov;386(11):991-9.
Inhibition of cardiac Kv1.5 and Kv4.3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode of action.[Pubmed: 23832378]
Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. For Ajmaline, inhibitory effects on a variety of cardiac K(+) channels have been observed, including cardiac Kv1 and Kv4 channels. However, the exact pharmacological properties of channel blockade have not yet been addressed adequately.
METHODS AND RESULTS:
Using two different expression systems, we analysed pharmacological effects of Ajmaline on the potassium channels Kv1.5 and Kv4.3 underlying cardiac I Kur and I to current, respectively. When expressed in a mammalian cell line, we find that Ajmaline inhibits Kv1.5 and Kv4.3 with an IC50 of 1.70 and 2.66 μM, respectively. Pharmacological properties were further analysed using the Xenopus expression system. We find that Ajmaline is an open channel inhibitor of cardiac Kv1.5 and Kv4.3 channels. Whereas Ajmaline results in a mild leftward shift of Kv1.5 activation curve, no significant effect on Kv4.3 channel activation could be observed. Ajmaline did not significantly affect channel inactivation kinetics. Onset of block was fast. For Kv4.3 channels, no significant effect on recovery from inactivation or channel deactivation could be observed. Furthermore, there was no use-dependence of block.
CONCLUSIONS:
Taken together, we show that Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations. These data add to the current understanding of the electrophysiological basis of anti-arrhythmic action of Ajmaline.
Daidzin 6''-O-malonate

Catalog No: CFN91028
CAS No: 124590-31-4
Price: $318/5mg
Pinoresinol 4-O-beta-D-glucopyrano...

Catalog No: CFN97180
CAS No: 69251-96-3
Price: $100/20mg
Glycyrrhizic acid ammonium salt

Catalog No: CFN99153
CAS No: 53956-04-0
Price: $40/20mg
beta-Eudesmol

Catalog No: CFN99537
CAS No: 473-15-4
Price: $288/20mg
Aloenin A

Catalog No: CFN93235
CAS No: 38412-46-3
Price: $ / mg
Gastrodin

Catalog No: CFN99549
CAS No: 62499-27-8
Price: $30/20mg
Liquiritin apioside

Catalog No: CFN90707
CAS No: 74639-14-8
Price: $90/20mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
Astrasieversianin VII

Catalog No: CFN90648
CAS No: 86764-11-6
Price: $238/10mg
DL-Syringaresinol

Catalog No: CFN99276
CAS No: 1177-14-6
Price: $ /
Tags: buy Ajmaline | Ajmaline supplier | purchase Ajmaline | Ajmaline cost | Ajmaline manufacturer | order Ajmaline | Ajmaline distributor