Liquiritin apioside | CAS:74639-14-8 | Manufacturer ChemFaces

Liquiritin apioside

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Description:

Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial injury in COPD.

Targets:

TNF-α | TGF-β/Smad

In vivo:

Fundam Clin Pharmacol. 2012 Aug;26(4):473-83.

Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. [Pubmed: 21631586]

Cigarette smoking is associated with an increased incidence of chronic obstructive pulmonary disease (COPD).
METHODS AND RESULTS:
In this study, we hypothesized that Liquiritin apioside (LA), a main flavonoid component from Glycyrrhiza uralensis, had antioxidant properties by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress. A549 cells were treated with cigarette smoke extract (CSE) and/or LA. ICR mice were exposed to cigarette smoke (CS) for four days with increasing exposure time for up to 6 h per day to elicit epithelial cells injury. One hour before smoke exposure, mice were treated with LA by gavage; 18 h after the last CS exposure all examinations were performed. Treatment with LA concentration-dependently prevented CSE-induced cytotoxicity, increase of TGF-β and TNF-α mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation. Lung sections of the CS-exposed LA treated mice showed an apparently reduced pulmonary inflammation and a significant inhibitory effect on mucus containing goblet cells in the large airways. Furthermore, the CS-induced pulmonary release of TGF-β, TNF-α and myeloperoxidase activity was reduced, and superoxide dismutase activity was enhanced.
CONCLUSIONS:
These results indicate that protective roles of LA on CS-induced the lung epithelial cell injury are mediated by inhibiting TGF-β and TNF-α expression and increasing anti-oxidative levels of GSH, suggesting that LA might be effective as protective agent against epithelial injury in COPD.

Liquiritin apioside Description

Source:	The roots of Glycyrrhiza uralensis Fisch
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Liquiritin apioside
Price:	$90 / 20mg
CAS No.:	74639-14-8
Catalog No.:	CFN90707
Molecular Formula:	C₂₆H₃₀O₁₃
Molecular Weight:	550.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Glycyrrhiza uralensis Fisch
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Antitussive Compound Library Lung protection Compound Library Flavonoids Compound Library TNF-α Inhibitor Library TGF-β/Smad Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8165 mL	9.0827 mL	18.1653 mL	36.3306 mL	45.4133 mL
5 mM	0.3633 mL	1.8165 mL	3.6331 mL	7.2661 mL	9.0827 mL
10 mM	0.1817 mL	0.9083 mL	1.8165 mL	3.6331 mL	4.5413 mL
50 mM	0.0363 mL	0.1817 mL	0.3633 mL	0.7266 mL	0.9083 mL
100 mM	0.0182 mL	0.0908 mL	0.1817 mL	0.3633 mL	0.4541 mL

CFN98878	Prunin	529-55-5	434.4	C₂₁H₂₂O₁₀
CFN99555	Naringin	10236-47-2	580.53	C₂₇H₃₂O₁₄
CFN95418	Naringin 6''-acetate	139934-60-4	622.6	C₂₉H₃₄O₁₅
CFN95419	Melitidin	1162664-58-5	724.7	C₃₃H₄₀O₁₈
CFN95380	Theaflavanoside II	943785-09-9	712.6	C₃₂H₄₀O₁₈
CFN95014	Naringin 4'-glucoside	17257-21-5	742.7	C₃₃H₄₂O₁₉
CFN95422	Bergamjuicin	2376307-20-7	886.8	C₃₉H₅₀O₂₃
CFN99543	Narirutin	14259-46-2	580.53	C₂₇H₃₂O₁₄
CFN95421	Narirutin 4'-glucoside	17257-22-6	742.7	C₃₃H₄₂O₁₉
CFN96142	Pyrroside B	116271-35-3	566.5	C₂₆H₃₀O₁₄