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Alepterolic acid
Alepterolic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Alepterolic acid
Price:
CAS No.: 63399-38-2
Catalog No.: CFN97091
Molecular Formula: C20H32O3
Molecular Weight: 320.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The rhizomes of Cibotium barometz (L.) J.Sm.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Alepterolic acid exhibits larvicidal properties against Aedes aegypti (L.) (Diptera, Culicidae), with LC50 of 87.3 ppm.
Alepterolic acid Description
Source: The rhizomes of Cibotium barometz (L.) J.Sm.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1201 mL 15.6006 mL 31.2012 mL 62.4025 mL 78.0031 mL
5 mM 0.624 mL 3.1201 mL 6.2402 mL 12.4805 mL 15.6006 mL
10 mM 0.312 mL 1.5601 mL 3.1201 mL 6.2402 mL 7.8003 mL
50 mM 0.0624 mL 0.312 mL 0.624 mL 1.248 mL 1.5601 mL
100 mM 0.0312 mL 0.156 mL 0.312 mL 0.624 mL 0.78 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Rev Inst Med Trop Sao Paulo. 2008 Jan-Feb;50(1):25-8.
Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae).[Pubmed: 18383630]
The objective of this study was to evaluate the larvicidal activity of diterpenoids obtained from the oil-resin of Copaifera reticulata against Aedes aegypti larvae, the principal vector of dengue and urban yellow fever.
METHODS AND RESULTS:
Four diterpenes were obtained from oil-resin extraction with organic solvents and subsequent chromatographic and spectroscopic procedures allowed to isolation and identification of these compounds as 3-beta-acetoxylabdan-8(17)-13-dien-15-oic acid (1), Alepterolic acid (2), 3-beta-hidroxylabdan-8(17)-en-15-oic acid (3), and ent-agatic acid (4). Each compound was previously dissolved in dimethylsulphoxide, and distilled water was added to obtain the desired concentrations. Twenty larvae of third instars were placed into plastic beckers, containing the solution test (25 mL), in a five repetitions scheme, and their mortality, indicated by torpor and darkening of the cephalic capsule, was recorded after 48 h. Probit analyses were used to determine lethal concentrations (LC50 and LC90) and their respective 95% confidence intervals.
CONCLUSIONS:
This study showed that only diterpenoids 1 and 2 exhibited larvicidal properties with LC50 of 0.8 ppm and 87.3 ppm, respectively, revealing the former as the most toxic compound against third instars of Ae. aegypti. Therefore, this compound seems to be an interesting source for new metabolite to be exploited.
CFN970903-Acetoxy-8(17),13E-labdadien-15-oic acid63399-37-1362.5 C22H34O4
CFN89391ent-3beta,18-Dihydroxylabda-8(17),13E-dien-15-oic acid99624-39-2336.46C20H32O4
CFN994129-Hydroxy-13E-labden-15-oic acid132915-47-0322.5 C20H34O3
CFN99303Coronarin B119188-38-4334.5 C20H30O4
CFN96361Metasequoic acid A113626-22-5302.5C20H30O2
CFN97440ent-14,15-Dinor-13-oxolabda-8(17),11-dien-18-oic acid875585-30-1290.4 C18H26O3
CFN92778Coronadiene1145689-64-0262.4C17H26O2
CFN9905815-Nor-14-oxolabda-8(17),12-dien-18-oic acid1039673-32-9304.4 C19H28O3
CFN89382Junicedric acid41787-69-3336.46C20H32O4
CFN92779Zerumin A176050-48-9318.5C20H30O3
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