Alpha-Terpineol | CAS:10482-56-1 | Manufacturer ChemFaces

Alpha-Terpineol

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Tormentic acid

Catalog No: CFN99434
CAS No: 13850-16-3
Price: $238/10mg

Jionoside A1

Catalog No: CFN90809
CAS No: 120444-60-2
Price: $238/5mg

Ganoderic acid A

Catalog No: CFN92051
CAS No: 81907-62-2
Price: $80/20mg

L-Menthol

Catalog No: CFN98123
CAS No: 2216-51-5
Price: $30/20mg

Glaucine

Catalog No: CFN90408
CAS No: 475-81-0
Price: $188/20mg

8-Prenylkaempferol

Catalog No: CFN92346
CAS No: 28610-31-3
Price: $ / mg

Zearalenone

Catalog No: CFN91172
CAS No: 17924-92-4
Price: $50/20mg

Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg

N-trans-caffeoyltyramine

Catalog No: CFN95265
CAS No: 103188-48-3
Price: $318/5mg

Cyanidin-3-O-galactoside chloride

Catalog No: CFN92040
CAS No: 27661-36-5
Price: $318/10mg

Description:

Alpha-Terpineol has antitumour, anti-inflammatory, and antimicrobial activities, it inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway; it can suppress the production of inflammatory mediators in LPS-stimulated human macrophages by interfering with the NF-kB, p38 or ERK MAPK pathways. Alpha-Terpineol may have utility as an anti-MRSA cleansing agent for dental instruments and dental unit chairs.

Targets:

In vitro:

Int J Oral Biol. 2013 Jun;38(2):51-54.

Antimicrobial Effects of Linalool and alpha-Terpineol against Methicillin-Resistant Staphylococcus aureus Isolated from Korean. [Reference: WebLink]

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the important causative microbes for nosocomial infection and has been isolated from the dental environment. The purpose of this study was to investigate the antimicrobial activity of linalool and Alpha-Terpineol against MRSA isolates from a Korean population. In the experiments, we determined the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of these two compounds against 18 strains of MRSA. The data revealed that the MIC90/MBC90 values of linalool and Alpha-Terpineol against MRSA were >12.8 mg/ml and 6.4 mg/ml, respectively. These results indicate that Alpha-Terpineol has more potent antimicrobial activity against MRSA than linalool and may have utility as an anti-MRSA cleansing agent for dental instruments and dental unit chairs.

Alpha-Terpineol Description

Source:	The herbs of Vitis vinifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Anticancer Res. 2010 Jun;30(6):1911-9.

Alpha-terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling.[Pubmed: 20651334]

Alpha-Terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity.
METHODS AND RESULTS:
The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed Alpha-Terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.
CONCLUSIONS:
The results suggest that Alpha-Terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway.

Inflamm Res. 2014 Sep;63(9):769-78.

Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages.[Pubmed: 24947163]

Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and Alpha-Terpineol) using lipopolysaccharide (LPS)-stimulated macrophages.
METHODS AND RESULTS:
The ability of TTO, terpinen-4-ol and Alpha-Terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-10 cytokine production and by western blotting for the activation of nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (MAPK) signaling, which are associated with the expression of pro-inflammatory cytokines. We used a human monocytic cell line (U937) differentiated into macrophages. LPS induced the production of all cytokines, and TTO and its components significantly reduced the production of IL-1β, IL-6 and IL-10. The production of TNF-α was not affected by either TTO or its major components. The modulation of cytokine production was not mediated by changes in NF-κB or p38 MAPK activation.
CONCLUSIONS:
TTO, terpinen-4-ol and Alpha-Terpineol can suppress the production of inflammatory mediators in LPS-stimulated human macrophages; this inhibition was mediated by interfering with the NF-kB, p38 or ERK MAPK pathways.

Product Name	Alpha-Terpineol
Price:
CAS No.:	10482-56-1
Catalog No.:	CFN80110
Molecular Formula:	C₁₀H₁₈O
Molecular Weight:	154.25 g/mol
Purity:	>=98%
Type of Compound:	Monoterpenoids
Physical Desc.:	Oil
Source:	The herbs of Vitis vinifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Monoterpenoids Compound Library TNF-α Inhibitor Library p38MAPK Inhibitor Library NF-kB Inhibitor Library IL Receptor Inhibitor Library ERK Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.483 mL	32.4149 mL	64.8298 mL	129.6596 mL	162.0746 mL
5 mM	1.2966 mL	6.483 mL	12.966 mL	25.9319 mL	32.4149 mL
10 mM	0.6483 mL	3.2415 mL	6.483 mL	12.966 mL	16.2075 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	2.5932 mL	3.2415 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.2966 mL	1.6207 mL

CFN97032	2-Hydroxy-1,8-cineole	60761-00-4	170.3	C₁₀H₁₈O₂
CFN92688	Terpineol	98-55-5	154.3	C₁₀H₁₈O
CFN80110	Alpha-Terpineol	10482-56-1	154.25	C₁₀H₁₈O
CFN94877	Terpinine-4-ol	562-74-3	154.3	C₁₀H₁₈O
CFN97064	p-Menthane-1,2,8-triol	62014-81-7	188.3	C₁₀H₂₀O₃
CFN99656	p-Menthane-1,3,8-triol	155348-06-4	188.3	C₁₀H₂₀O₃
CFN98795	Oleuropeic acid	5027-76-9	184.2	C₁₀H₁₆O₃
CFN93581	Perillyl alcohol	536-59-4	152.2	C₁₀H₁₆O
CFN96125	Oleuropeic acid 8-O-glucoside	865887-46-3	346.4	C₁₆H₂₆O₈
CFN99285	Cuniloside B	1187303-40-7	512.6	C₂₆H₄₀O₁₀