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Anonamine
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Product Name Anonamine
Price:
CAS No.: 111566-66-6
Catalog No.: CFN00427
Molecular Formula: C19H27NO7
Molecular Weight: 381.42 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Senecio scandens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Anonamine is a natural product from Senecio scandens.
In vitro:
J Nat Prod. 1988 Jul-Aug;51(4):690-702.
Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography.[Pubmed: 3210016]

METHODS AND RESULTS:
Ten 12-membered macrocyclic pyrrolizidine alkaloids, all of them esters of the necines, retronecine or otonecine, have been isolated from Senecio anonymus. The separation, carried out by droplet counter-current chromatography, afforded senecionine [1], integerrimine [2], retrorsine [3], senkirkine [5], neosenkirkine [6], otosenine [10], hydroxysenkirkine [7], and a new alkaloid given the trivial name Anonamine [9]. Traces of usaramine [4] and another new alkaloid, hydroxyneosenkirkine [8], were detected by 1H nmr. In addition, the previously unreported 3a beta-hydroxy-4-ethoxy-2,6-perhydroindoledione [11] was isolated. X-ray structures were obtained for neosenkirkine [6], hydroxysenkirkine [7], Anonamine [9], and [11].
CONCLUSIONS:
1H-13C heteronuclear shift correlated nmr (HETCOR) provided unambiguous chemical shift assignments for 13C-nmr data. Antitumor activity was assayed using the A204-rhabdomyosarcoma cell line in soft agarose.
Anonamine Description
Source: The herbs of Senecio scandens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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doi: 10.1016/j.cmet.2020.01.002.
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PMID: 32004475

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6218 mL 13.1089 mL 26.2178 mL 52.4356 mL 65.5445 mL
5 mM 0.5244 mL 2.6218 mL 5.2436 mL 10.4871 mL 13.1089 mL
10 mM 0.2622 mL 1.3109 mL 2.6218 mL 5.2436 mL 6.5545 mL
50 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.0487 mL 1.3109 mL
100 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.5244 mL 0.6554 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 1991 Sep-Oct;54(5):1425-6.
Acetylanonamine, a new secopyrrolizidine alkaloid from Senecio anonymus.[Pubmed: 1800641]
A new secopyrrolizidine alkaloid, acetylAnonamine, was isolated from Senecio anonymus.
METHODS AND RESULTS:
The structure was established by high resolution nmr (1H-1H COSY and 1H-13C HETCOR), ms, comparison of these spectral data with those of Anonamine, and synthesis of 1 from 2.
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