Alpha-pinene | CAS:80-56-8 | Manufacturer ChemFaces

Alpha-pinene

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Description:

Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression. Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels.

Targets:

NF-kB | p65 | ROS

In vitro:

Acta Pharmacol Sin. 2004 Apr;25(4):480-4.

Effect of alpha-pinene on nuclear translocation of NF-kappa B in THP-1 cells.[Pubmed: 15066217]

METHODS AND RESULTS:
To study the effects of Alpha-pinene on nuclear translocation of nuclear factor-kappa B (NF-kappa B) and the expression of the inhibitThe majority of FITC-labelled NF-kappa B/p65 was located in the nuclei being stimulated with LPS. Whereas, no such fluorescence was seen in the nuclei of the groups pretreated with Alpha-pinene or control cells. Alpha-pinene pretreatment decreased the NF-kappa B/p65 nuclear translocation in LPS-stimulated THP-1 cells, and this effect was dose-dependent, but there was no reaction in LPS-unstimulated THP-1 cells. Alpha-pinene pretreatment increased I kappa B alpha protein level in cytoplasm, compared with that in LPS-stimulated THP-1 cells.
CONCLUSIONS:
In a dose-related fashion, Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression.or of NF-kappa B (I kappa B alpha) in human monocyte THP-1 cell line.

Alpha-pinene Description

Source:	The heartwoods of Pinus armandii Franch.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Ann Bot. 2006 Dec;98(6):1261-9.

alpha-Pinene inhibits growth and induces oxidative stress in roots.[Pubmed: 17028297 ]

Determining the mode of action of allelochemicals is one of the challenging aspects in allelopathic studies. Recently, allelochemicals have been proposed to cause oxidative stress in target tissue and induce an antioxidant mechanism. Alpha-pinene, one of the common monoterpenoids emitted from several aromatic plants including forest trees, is known for its growth-inhibitory activity. However, its mechanism of action remains unexplored.
METHODS AND RESULTS:
The aim of the present study was to determine the inhibitory effect of Alpha-pinene on root growth and generation of reactive oxygen species, as indicators of oxidative stress and changes in activities of antioxidant enzymes.Alpha-pinene inhibited the radicle growth of all the test species. Exposure of C. occidentalis roots to Alpha-pinene enhanced solute leakage, and increased levels of malondialdehyde, proline and hydrogen peroxide, indicating lipid peroxidation and induction of oxidative stress. Activities of the antioxidant enzymes SOD, CAT, GPX, APX and GR were significantly elevated, thereby indicating the enhanced generation of reactive oxygen species (ROS) upon Alpha-pinene exposure. Increased levels of scavenging enzymes indicates their induction as a secondary defence mechanism in response to Alpha-pinene.
CONCLUSIONS:
It is concluded that Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels.

Product Name	Alpha-pinene
Price:	$30 / 20mg
CAS No.:	80-56-8
Catalog No.:	CFN93285
Molecular Formula:	C₁₀H₁₆
Molecular Weight:	136.2 g/mol
Purity:	>=98%
Type of Compound:	Monoterpenoids
Physical Desc.:	Oil
Source:	The heartwoods of Pinus armandii Franch.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-plant-germination and growth Compound Library Pro-oxidants Compound Library Monoterpenoids Compound Library ROS Inhibitor Library p65 Inhibitor Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.3421 mL	36.7107 mL	73.4214 mL	146.8429 mL	183.5536 mL
5 mM	1.4684 mL	7.3421 mL	14.6843 mL	29.3686 mL	36.7107 mL
10 mM	0.7342 mL	3.6711 mL	7.3421 mL	14.6843 mL	18.3554 mL
50 mM	0.1468 mL	0.7342 mL	1.4684 mL	2.9369 mL	3.6711 mL
100 mM	0.0734 mL	0.3671 mL	0.7342 mL	1.4684 mL	1.8355 mL

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CFN95106	Isololiolide	38274-00-9	196.2	C₁₁H₁₆O₃
CFN97070	4-Hydroxy-2,6,6-trimethyl-1-cyclohexenecarboxylic acid	62218-55-7	184.2	C₁₀H₁₆O₃
CFN91691	Rehmapicrogenin	135447-39-1	184.2	C₁₀H₁₆O₃
CFN90760	Rehmapicroside	104056-82-8	346.4	C₁₆H₂₆O₈
CFN91177	Picrocrocin	138-55-6	330.4	C₁₆H₂₆O₇
CFN93287	Beta-pinene	18172-67-3	136.2	C₁₀H₁₆
CFN93285	Alpha-pinene	80-56-8	136.2	C₁₀H₁₆