Bergaptol | CAS:486-60-2 | Manufacturer ChemFaces

Bergaptol

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Size /Price /Stock	10 mM * 1 mL in DMSO / $34.9 / In-stock
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Description:

Bergaptol acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.Bergaptol shows very good radical scavenging activity, it induces dose-dependent cytotoxic effect on MCF-7 cell viability.

Targets:

CYP3A4

In vitro:

Bangl. J. Pharmacol., 2016, 11(2):489.

Antitumor and apoptotic effects of bergaptol are mediated via mitochondrial death pathway and cell cycle arrest in human breast carcinoma cells.[Reference: WebLink]

The aim of the present research work was to investigate the anti-cancer and apoptotic effects of Bergaptol in human breast cancer cells (MCF-7).
METHODS AND RESULTS:
The effects on cell cycle arrest and caspase activation were evaluated. MTT assay was used to evaluate the effect of the compound on cell viability. Cellular morphology was demonstrated by fluorescence microscopy. Flow cytometry was used to analyze effect of Bergaptol on cell cycle and apoptosis. The results revealed that Bergaptol induced dose-dependent cytotoxic effect on MCF-7 cell viability showing IC50 value of 52.2 μM. Bergaptol induced both early and late apoptosis in concentration-dependent manner. After treatment with Bergaptol, an increase in the proportion of cells in the S-phase (37.2, 45.3 and 65.1% as compared to 28.6% in untreated cells) and a reduction in the fraction of cells in the G1 phase (44.1, 41.6 and 35.2% as compared to 51.2% in the untreated cells) was observed.

Bergaptol Description

Source:	The roots of Notopterygium incisum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Bioorg Med Chem. 2007 Jun 1;15(11):3684-91.

Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.[Pubmed: 17400460]

Grapefruit juice has been shown to increase the oral bioavailability of several clinically important drugs by inhibiting first pass metabolism. Several compounds in grapefruit juice have shown different biological activities. Unique among them are furocoumarins with potent inhibitory activity against cytochrome P450 enzymes.
METHODS AND RESULTS:
In the present study, two bioactive compounds were isolated from grapefruit juice and grapefruit peel oil. The purity of the isolated compounds has been analyzed by HPLC. Structures of the compounds were elucidated by extensive NMR and mass spectral studies and identified as Bergaptol and geranylcoumarin. The isolated compounds were tested for their radical scavenging activity using 2,2'-azobis (3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazil (DPPH) methods at different concentrations. Bergaptol showed very good radical scavenging activity at all the tested concentrations. Furthermore, these compounds were evaluated for their inhibitory activity against CYP3A4 enzyme.
CONCLUSIONS:
Bergaptol and geranylcoumarin were found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC(50) value of 24.92 and 42.93 microM, respectively.

Product Name	Bergaptol
Price:	$198 / 20mg
CAS No.:	486-60-2
Catalog No.:	CFN98772
Molecular Formula:	C₁₁H₆O₄
Molecular Weight:	202.2 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Yellow powder
Source:	The roots of Notopterygium incisum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Inhibitors Compound Library Cytotoxic Compound Library Pro-apoptotic Compound Library Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.9456 mL	24.728 mL	49.456 mL	98.912 mL	123.64 mL
5 mM	0.9891 mL	4.9456 mL	9.8912 mL	19.7824 mL	24.728 mL
10 mM	0.4946 mL	2.4728 mL	4.9456 mL	9.8912 mL	12.364 mL
50 mM	0.0989 mL	0.4946 mL	0.9891 mL	1.9782 mL	2.4728 mL
100 mM	0.0495 mL	0.2473 mL	0.4946 mL	0.9891 mL	1.2364 mL

CFN90591	8-Hydroxybergapten	1603-47-0	232.19	C₁₂H₈O₅
CFN98752	Isopimpinellin	482-27-9	246.2	C₁₃H₁₀O₅
CFN99893	Rivulobirin B	194145-29-4	432.3	C₂₃H₁₂O₉
CFN70355	Trioxsalen	3902-71-4	228.2	C₁₄H₁₂O₃
CFN98016	Xanthotoxol	2009-24-7	202.2	C₁₁H₆O₄
CFN98372	Xanthotoxin	298-81-7	216.2	C₁₂H₈O₄
CFN95186	Bergaptol-beta-glucopyranoside	131623-13-7	364.3	C₁₇H₁₆O₉
CFN98663	8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen	425680-98-4	380.3	C₁₇H₁₆O₁₀
CFN98772	Bergaptol	486-60-2	202.2	C₁₁H₆O₄
CFN98766	Bergapten	484-20-8	216.2	C₁₂H₈O₄