Bis-5,5-nortrachelogenin | CAS:870480-56-1

Bis-5,5-nortrachelogenin

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Description:

Bis-5,5-nortrachelogenin has anti-allergic activity, it inhibited NO production with IC50 value of 48.6 microM.

Targets:

In vitro:

Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1348-51.

Lignans from the roots of Wikstroemia indica and their DPPH radical scavenging and nitric oxide inhibitory activities.[Pubmed: 16205001]

METHODS AND RESULTS:
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of two new lignan dimer Bis-5,5-nortrachelogenin (1) and bis-5,5'-nortrachelogenin (2), and three known lignans.
CONCLUSIONS:
Compound 1 and lirioresinol B (5) inhibited NO production with IC50 values at 48.6 and 53.5 microM, respectively. Compound 5 also showed free radical scavenging effect on 1,1-diphenyl-2-picrylhydrazil (DPPH) at IC50 values at 19.5 microM.

Bis-5,5-nortrachelogenin Description

Source:	The roots of Wikstroemia indica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bis-5,5-nortrachelogenin
Price:
CAS No.:	870480-56-1
Catalog No.:	CFN96251
Molecular Formula:	C₄₀H₄₂O₁₄
Molecular Weight:	746.8 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The roots of Wikstroemia indica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.339 mL	6.6952 mL	13.3905 mL	26.7809 mL	33.4762 mL
5 mM	0.2678 mL	1.339 mL	2.6781 mL	5.3562 mL	6.6952 mL
10 mM	0.1339 mL	0.6695 mL	1.339 mL	2.6781 mL	3.3476 mL
50 mM	0.0268 mL	0.1339 mL	0.2678 mL	0.5356 mL	0.6695 mL
100 mM	0.0134 mL	0.067 mL	0.1339 mL	0.2678 mL	0.3348 mL

CFN95251	Nortrachelogenin-5'-C-beta-glucoside	858127-39-6	536.5	C₂₆H₃₂O₁₂
CFN96608	Traxillaside	149415-62-3	564.59	C₂₈H₃₆O₁₂
CFN89466	Trachelosiaside	106647-12-5	520.52	C₂₆H₃₂O₁₁
CFN92491	Styraxlignolide F	823214-06-8	534.6	C₂₇H₃₄O₁₁
CFN98281	2,3-Bis(3,4-dimethoxybenzyl)butyrolactone	25488-59-9	386.4	C₂₂H₂₆O₆
CFN97182	Tupichilignan A	69586-96-5	402.4	C₂₂H₂₆O₇
CFN97230	5-Acetoxymatairesinol dimethyl ether	74892-45-8	444.5	C₂₄H₂₈O₈
CFN92059	Pluviatolide	28115-68-6	356.4	C₂₀H₂₀O₆
CFN97234	Kaerophyllin	75590-33-9	368.4	C₂₁H₂₀O₆
CFN99313	Meridinol	120051-54-9	370.4	C₂₀H₁₈O₇