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Bonducellin
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Product Name Bonducellin
Price: $368 / 5mg
CAS No.: 83162-84-9
Catalog No.: CFN96509
Molecular Formula: C17H14O4
Molecular Weight: 282.29 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Caesalpinia spinosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $257.6 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial activity against Plasmodium falciparum with the IC50 value of 26 uM; it also shows weak antiproliferative against A2780 human ovarian cancer cell line , with the IC50 value of 10.6 uM. Bonducellin shows modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also shows significant efflux pump inhibitory activity.
Targets: NO | NF-kB | IL Receptor | IFN-γ | TNF-α | Antifection
In vitro:
Bioorg Med Chem. 2013 Dec 15;21(24):7591-4.
Bioactive compounds from Stuhlmannia moavi from the Madagascar dry forest.[Pubmed: 24239390 ]

METHODS AND RESULTS:
Bioassay-directed fractionation of the leaf and root extracts of the antiproliferative Madagascar plant Stuhlmannia moavi afforded 6-acetyl-5,8-dihydroxy-2-methoxy-7-methyl-1,4-naphthoquinone (stuhlmoavin, 1) as the most active compound, with an IC50 value of 8.1 μM against the A2780 human ovarian cancer cell line, as well as the known homoisoflavonoid Bonducellin (2) and the stilbenoids 3,4,5'-trihydroxy-3'-methoxy-trans-stilbene (3), piceatannol (4), resveratrol (5), rhapontigenin (6), and isorhapontigenin (7). The structure elucidation of all compounds was based on NMR and mass spectroscopic data, and the structure of 1 was confirmed by a single crystal X-ray analysis.
CONCLUSIONS:
Compounds 2-5 showed weak A2780 activities, with IC50 values of 10.6, 54.0, 41.0, and 74.0 μM, respectively. Compounds 1-3 also showed weak antimalarial activity against Plasmodium falciparum with IC50 values of 23, 26, and 27 μM, respectively.
Eur J Med Chem. 2013 Aug;66:499-507.
7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc2 155.[Pubmed: 23832254]
Efflux pump (EP) induces resistance in mycobacteria and hence could be explored as a new target for the discovery of anti-TB agents. In search for efflux pump inhibitors from natural products, Bonducellin, a homoisoflavonoid was isolated from Caesalpinia digyna roots and evaluated for modulation and EP inhibitory activity.
METHODS AND RESULTS:
Bonducellin showed modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also showed significant EP inhibitory activity. A synthetic scheme was designed to prepare analogues of 7-hydroxy-(E)-3-phenylmethylene-chroman-4-one by modification at the phenylmethylene-ring and the synthesized compounds were evaluated in accumulation and efflux assays.
CONCLUSIONS:
Analogues 1, 7-11, 13-15, 17 and 19 were found to be good modulators and decreased the MIC of EtBr by ≥4 fold at sub-inhibitory concentration. The compounds 8, 13 and 17 were the most potent inhibitors of ethidium bromide efflux in Mycobacterium smegmatis mc(2) 155.
Bonducellin Description
Source: The herbs of Caesalpinia spinosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5425 mL 17.7123 mL 35.4246 mL 70.8491 mL 88.5614 mL
5 mM 0.7085 mL 3.5425 mL 7.0849 mL 14.1698 mL 17.7123 mL
10 mM 0.3542 mL 1.7712 mL 3.5425 mL 7.0849 mL 8.8561 mL
50 mM 0.0708 mL 0.3542 mL 0.7085 mL 1.417 mL 1.7712 mL
100 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.7085 mL 0.8856 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
J Ethnopharmacol. 2005 Sep 14;100(3):249-53.
Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima.[Pubmed: 15893896]

METHODS AND RESULTS:
The anti-inflammatory activities of five flavonoids, namely 5,7-dimethoxyflavanone (1), 5,7-dimethoxy-3',4'-methylenedioxyflavanone (2), isoBonducellin (3), 2'-hydroxy-2,3,4',6'-tetramethoxychalcone (4) and Bonducellin (5), all of them isolated from Caesalpinia pulcherrima L. was studied in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages. These five compounds significantly and dose-dependently inhibited the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. According to their inhibitory results, the order of anti-inflammatory potency was compounds 3>5>4>2>1. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-gamma for 24h, and determined the inhibitory effects of the above-mentioned isolates on the production of NO after a further 24h.
CONCLUSIONS:
The present study supports the use of Caesalpinia pulcherrima for the treatment of inflammatory diseases in traditional medicine. This is the first study on compounds 1-5 about their anti-inflammatory activities.
Friedelin

Catalog No: CFN98936
CAS No: 559-74-0
Price: $218/10mg
Licoricesaponin G2

Catalog No: CFN92915
CAS No: 118441-84-2
Price: $368/20mg
(2RS)-Lotaustralin

Catalog No: CFN90968
CAS No: 1973415-50-7
Price: $268/5mg
Clinopodiside A

Catalog No: CFN90479
CAS No: 142809-89-0
Price: $122/20mg
(+)-Sophoranol

Catalog No: CFN92840
CAS No: 3411-37-8
Price: $ / mg
Tetrahydrocurcumin

Catalog No: CFN90583
CAS No: 36062-04-1
Price: $30/20mg
Piperlonguminine

Catalog No: CFN91121
CAS No: 5950-12-9
Price: $288/20mg
Lasiocarpine

Catalog No: CFN00289
CAS No: 303-34-4
Price: $ /
Oxypeucedanin

Catalog No: CFN90350
CAS No: 737-52-0
Price: $80/20mg
Triptolide

Catalog No: CFN99196
CAS No: 38748-32-2
Price: $118/20mg
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