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Burchellin
Burchellin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Burchellin
Price:
CAS No.: 38276-59-4
Catalog No.: CFN96386
Molecular Formula: C20H20O5
Molecular Weight: 340.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Ocotea cymbarum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
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  • Universidad de La Salle (Mexico)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Burchellin has larvicidal activity, it can interfer with the development cycle of the mosquito, where its strongest toxic effect is 100% mortality in larvae (L3) at concentrations ≥ 30 ppm. Burchellin and licarin A have activity against Trypanosoma cruzi, they can induce trypomastigote death with IC(50)/24 h of 520 microM and 960 microM, respectively.
Targets: Antifection
In vitro:
Parasit Vectors. 2014 Apr 8;7:172.
Burchellin: study of bioactivity against Aedes aegypti.[Pubmed: 24713267]
The dengue mosquito Aedes aegypti Linnaeus, 1762 is a widespread insect pest of serious medical importance. Since no effective vaccine is available for treating dengue, the eradication or control of the main mosquito vector is regarded as essential. Since conventional insecticides have limited success, plants may be an alternative source of larvicidal agents, since they contain a rich source of bioactive chemicals. The aim of this study was to evaluate the larvicidal activity of the neolignan Burchellin isolated from Ocotea cymbarum (Lauraceae), a plant from the Amazon region, against third instar larvae of A. aegypti.
METHODS AND RESULTS:
Burchellin obtained from O. cymbarum was analyzed. The inhibitory activity against A. aegypti eggs and larvae and histological changes in the digestive system of treated L3 larvae were evaluated. In addition, nitric oxide synthase activity and nitric oxide levels were determined, and cytotoxicity bioassays performed. The data showed that Burchellin interfered with the development cycle of the mosquito, where its strongest toxic effect was 100% mortality in larvae (L3) at concentrations ≥ 30 ppm. This compound did not show target cell toxicity in peritoneal macrophages from BALB/c mice, and proved to have molecular stability when dissolved in water. The L3 and L4 larvae treated with the compound showed cellular destruction and disorganization, cell spacing, and vacuolization of epithelial cells in small regions of the midgut.
CONCLUSIONS:
The neolignan Burchellin proved to be a strong candidate for a natural, safe and stable phytolarvicidal to be used in population control of A. aegypti.
Exp Parasitol. 2010 Mar;124(3):319-24.
Neolignans from plants in northeastern Brazil (Lauraceae) with activity against Trypanosoma cruzi.[Pubmed: 19944690 ]
Trypanosoma cruzi is the ethiological agent for Chagas disease in Latin America. This study aimed to test the trypanocidal effect of licarin A and Burchellin isolated from plants in northeastern Brazil.
METHODS AND RESULTS:
These neolignans were tested on T. cruzi and on peritoneal macrophages, to evaluate drug toxicity. Epimastigote growth was inhibited in 45% with licarin A and 20% with Burchellin with an IC(50)/96 h of 462.7 microM and 756 microM, respectively. Epimastigotes treated with licarin A presented swollen mitochondria and disorganized mitochondrial cristae, kDNA and Golgi complex. When treated with Burchellin, they presented enormous autophagosomes and chromatin disorganization. Licarin A and Burchellin were able to induce trypomastigote death with IC(50)/24 h of 960 microM and 520 microM, respectively. Although licarin A presented an IC(50) for trypomastigotes higher than for epimastigotes, both substances acted as therapeutic trypanocidal agents, because they were able to kill parasites without affecting macrophages.
CONCLUSIONS:
Due to our results, Burchellin and licarin A need to be further analysed to observe if they may be used as alternative blood additive prophylaxis against Chagas disease, since it has been established that blood transfusion is an important mechanism in the transmission process.
Burchellin Description
Source: The herbs of Ocotea cymbarum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

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IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9377 mL 14.6886 mL 29.3772 mL 58.7544 mL 73.443 mL
5 mM 0.5875 mL 2.9377 mL 5.8754 mL 11.7509 mL 14.6886 mL
10 mM 0.2938 mL 1.4689 mL 2.9377 mL 5.8754 mL 7.3443 mL
50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.1751 mL 1.4689 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.5875 mL 0.7344 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Cyanidin-3-O-galactoside chloride

Catalog No: CFN92040
CAS No: 27661-36-5
Price: $318/10mg
(+)-Pteryxin

Catalog No: CFN92559
CAS No: 13161-75-6
Price: $188/20mg
Butein

Catalog No: CFN98776
CAS No: 487-52-5
Price: $100/20mg
Nobiletin

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Price: $30/20mg
Fisetin

Catalog No: CFN98176
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Price: $30/20mg
Licochalcone A

Catalog No: CFN99575
CAS No: 58749-22-7
Price: $88/20mg
Stigmasterol

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CAS No: 83-48-7
Price: $30/20mg
Bakuchalcone

Catalog No: CFN92229
CAS No: 84575-13-3
Price: $ / mg
Apigenin

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Price: $40/20mg
Hirsuteine

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