Carmine | CAS:2611-82-7 | Manufacturer ChemFaces

Carmine

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $14.0 / In-stock
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Description:

Carmine is used in the manufacture of artificial flowers, paints, crimson ink, rouge, and other cosmetics, and is routinely added to food products such as yogurt, candy and certain brands of juice, the most notable ones being those of the ruby-red variety.There are many reported cases of immediate allergy after ingestion of foods containing cochineal and have a few reports of allergic contact dermatitis from carmine, suggests that carmine is an allergen.

In vivo:

Dermatitis. 2011 Nov-Dec;22(6):348-9.

Allergic contact dermatitis from carmine in cosmetic blush.[Pubmed: 22653009]

Although there are many reported cases of immediate allergy after ingestion of foods containing cochineal, there are few reports of allergic contact dermatitis from Carmine.
METHODS AND RESULTS:
We present a rare case of allergic contact dermatitis due to Carmine. A 52-year-old female presented with an itchy erythema on her cheeks at the site where blush had been applied. Patch-tested with her cosmetics, she showed a positive reaction to the blush (30% in petrolatum) and to 0.2% (but not 0.1%) Carmine in petrolatum. In this case, the optimum patch-test concentration of Carmine was 0.2% in petrolatum.

J Clin Monit Comput. 2015 Jun 17.

Effects of indigo carmine intravenous injection on noninvasive and continuous total hemoglobin measurement.[Pubmed: 26076807]

The effects of an intravenous injection of indigo Carmine on noninvasive and continuous total hemoglobin (SpHb) measurement were retrospectively evaluated.
METHODS AND RESULTS:
The subjects were 21 patients who underwent elective gynecologic surgery under general anesthesia. During surgery, 5 mL of 0.4 % indigo Carmine was intravenously injected, and subsequent changes in SpHb concentrations were evaluated. The results demonstrate that the pre-injection SpHb level was 10 g/dL, and the minimum post-injection SpHb level was 8.3 g/dL. The amount of decrease was 1.8 g/dL. The time to reach the minimum value was 4 min, and the time to return to the pre-injection value was 15 min. The decrease in SpHb was greater in the group with a perfusion index (PI) < 1.4 than in the group with a PI > 1.4.
CONCLUSIONS:
The assessment of SpHb after an intravenous injection of indigo Carmine necessitates caution.

Carmine Description

Source:	The coloring matter from the insect Coccus cacti L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Open Orthop J. 2013;7:8-11.

Effects of indigo carmine on human chondrocytes in vitro.[Pubmed: 23341851]

Joint infections following or accompanying superficious soft tissue infections are severe complication in orthopedic surgery. The use of intra-articular blue staining is a helpful method to visualize a fistula and to differentiate between superficial and intra-articular infections. Regarding this clinical implication data about the effects of indigo Carmine, a frequently used blue staining substance, on cartilage is missing.
METHODS AND RESULTS:
The hypothesis of this study was that indigo Carmine damages human chondrocytes in a time and concentration dependent manner. Human chondrocytes were isolated from donors with osteoarthritis who were treated with TKA. Cells were cultivated and treated with different concentrations of indigo Carmine for 5 and 10 minutes. Morphologic damage was examined by light microscopy. Toxicity was quantified by counting vital cell number and lactate dehydrogenase (LDH) expression. Analysis by light microscopy showed defected cell structure and loss of cell number after treatment with 100% indigo Carmine for 10 minutes. Treatment with 10% and 1% indigo Carmine showed no significant cell defects and loss of cells. Counting vital cell number showed loss of vital cells after treatment with 100% and 10% indigo Carmine for 10 minutes. LDH expression was significantly increased after treatment with 100% indigo Carmine.Toxic effects were shown after treatment with indigo Carmine.
CONCLUSIONS:
Therefore, it should be used in 1:100 dilution. This is both, sufficient for visualizing a fistula in a possible clinical application and could be protective for chondrocytes.

Product Name	Carmine
Price:	$30 / 20mg
CAS No.:	2611-82-7
Catalog No.:	CFN90066
Molecular Formula:	C₂₀H₁₁N₂O₁₀S₃
Molecular Weight:	534.9 g/mol
Purity:	>=98%
Type of Compound:	Anthraquinones
Physical Desc.:	Red powder
Source:	The coloring matter from the insect Coccus cacti L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Food additives Compound Library Pigments Compound Library Cosmetic additives Compound Library Allergens Compound Library Anthraquinones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8695 mL	9.3475 mL	18.6951 mL	37.3902 mL	46.7377 mL
5 mM	0.3739 mL	1.8695 mL	3.739 mL	7.478 mL	9.3475 mL
10 mM	0.187 mL	0.9348 mL	1.8695 mL	3.739 mL	4.6738 mL
50 mM	0.0374 mL	0.187 mL	0.3739 mL	0.7478 mL	0.9348 mL
100 mM	0.0187 mL	0.0935 mL	0.187 mL	0.3739 mL	0.4674 mL

CFN93322	Chrysophanol 1-O-glucoside	4839-60-5	416.38	C₂₁H₂₀O₉
CFN91124	Chrysophanol 1-O-beta-tetraglucoside	120181-08-0	902.8	C₃₉H₅₀O₂₄
CFN93238	Emodin 1-O-beta-D-glucoside	38840-23-2	432.38	C₂₁H₂₀O₁₀
CFN70270	Frangulin B	14101-04-3	402.4	C₂₀H₁₈O₉
CFN70393	Frangulin A	521-62-0	416.4	C₂₁H₂₀O₉
CFN91773	Emodin 6-O-beta-D-glucoside	34298-85-6	432.38	C₂₁H₂₀O₁₀
CFN99572	Emodin-8-beta-D-glucoside	23313-21-5	432.41	C₂₁H₂₀O₁₀
CFN95132	Emodin-8-O-beta-gentiobioside	66466-22-6	594.5	C₂₇H₃₀O₁₅
CFN80399	Physcion 8-O-beta-D-monoglucoside	23451-01-6	446.4	C₂₂H₂₂O₁₀
CFN89023	Physcion 8-O-rutinoside	129393-21-1	592.55	C₂₈H₃₂O₁₄