Catalponol | CAS:34168-56-4 | Manufacturer ChemFaces

Catalponol

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Catalponol Description

Source:	The roots of Ekmanianthe longiflora.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

J Asian Nat Prod Res. 2009 Oct;11(10):867-75.

Catalponol enhances dopamine biosynthesis and protects against L-DOPA-induced cytotoxicity in PC12 cells.[Pubmed: 20183248]

The effects of Catalponol (1) on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells were investigated.
METHODS AND RESULTS:
Catalponol at concentration ranges of 1-5 microM increased the intracellular levels of dopamine at 12-48 h. Catalponol at concentrations of up to 10 microM did not alter cell viability. Tyrosine hydroxylase (TH) activity was enhanced by Catalponol at 3 microM in a time-dependent manner, but aromatic L-amino acid decarboxylase activity was not. Catalponol also increased the intracellular levels of cyclic AMP and TH phosphorylation. In addition, Catalponol at 3 microM associated with L-DOPA (20-50 microM) further enhanced the increases in dopamine levels induced by L-DOPA (50-100 microM) at 24 h. Catalponol at 2-5 microM inhibited L-DOPA (100-200 microM)-induced cytotoxicity at 48 h.
CONCLUSIONS:
These results suggest that Catalponol enhanced dopamine biosynthesis by inducing TH activity and protected against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP.

Product Name	Catalponol
Price:
CAS No.:	34168-56-4
Catalog No.:	CFN98441
Molecular Formula:	C₁₅H₁₈O₂
Molecular Weight:	230.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The roots of Ekmanianthe longiflora.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Sesquiterpenoids Compound Library cAMP Inhibitor Library

Description:	Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP.
Targets:	cAMP

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.3422 mL	21.7108 mL	43.4216 mL	86.8432 mL	108.5541 mL
5 mM	0.8684 mL	4.3422 mL	8.6843 mL	17.3686 mL	21.7108 mL
10 mM	0.4342 mL	2.1711 mL	4.3422 mL	8.6843 mL	10.8554 mL
50 mM	0.0868 mL	0.4342 mL	0.8684 mL	1.7369 mL	2.1711 mL
100 mM	0.0434 mL	0.2171 mL	0.4342 mL	0.8684 mL	1.0855 mL

CFN98441	Catalponol	34168-56-4	230.3	C₁₅H₁₈O₂
CFN98311	3-Hydroxycatalponol	265644-24-4	246.3	C₁₅H₁₈O₃
CFN99688	1-Hydroxy-2-prenylnaphthalene	16274-34-3	212.3	C₁₅H₁₆O
CFN99687	3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran	16274-33-2	212.3	C₁₅H₁₆O
CFN98930	Mollugin	55481-88-4	284.3	C₁₇H₁₆O₄
CFN95424	3-Hydroxymollugin	154706-45-3	300.3	C₁₇H₁₆O₅
CFN96857	3-Methoxymollugin	154706-44-2	314.33	C₁₈H₁₈O₅
CFN91030	Dihydromollugin	60657-93-4	286.32	C₁₇H₁₈O₄
CFN96847	Nonin A	1357351-29-1	300.31	C₁₇H₁₆O₅
CFN97055	Furomollugin	61658-41-1	242.2	C₁₄H₁₀O₄