Caulophine | CAS:1159989-19-1 | Manufacturer ChemFaces

Caulophine

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Description:

Caulophine has the ability to protect cardiomyocytes from oxidative and ischemic injury through an antioxidative mechanism.

Targets:

SOD

In vitro:

J Pharmacol Sci. 2010;113(4):368-77.

Caulophine protects cardiomyocytes from oxidative and ischemic injury.[Pubmed: 20724803]

Caulophine is a new fluorenone alkaloid isolated from the radix of Caulophyllum robustum MAXIM and identified as 3-(2-(dimethylamino) ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one. Due to its new chemical structure, the pharmacological activities of Caulophine are not well characterized. The present study evaluated the protective effect and the primary mechanisms of Caulophine on cardiomyocyte injury.
METHODS AND RESULTS:
Viability of cardiomyocytes was assayed with the MTT method, and cell apoptosis was detected by flow cytometry. Myocardial infarction was produced by ligating the coronary artery, and myocardial ischemia was induced by isoproterenol in rats. Myocardial infarction size was estimated with p-nitro-blue tetrazolium staining. Lactate dehydrogenase (LDH), creatine kinase (CK), superoxide dismutase (SOD), malondialdehyde (MDA), and free fatty acid (FFA) were spectrophotometrically determined. Histopathological and ultrastructural changes of ischemic myocardium were observed. The results showed that pretreatment with Caulophine increased the viability of H(2)O(2)- and adriamycin-injured cardiomyocytes; decreased CK, LDH, and MDA; increased SOD; and inhibited H(2)O(2)-induced cellular apoptosis. Caulophine reduced myocardial infarct size and serum CK, LDH, FFA, and MDA; raised serum SOD; and improved histopathological and ultrastructural changes of ischemic myocardium.
CONCLUSIONS:
The results demonstrate that Caulophine has the ability to protect cardiomyocytes from oxidative and ischemic injury through an antioxidative mechanism that provides a basis for further study and development of Caulophine as a promising agent for treating coronary heart disease.

Caulophine Description

Source:	The herbs of Caulophyllum robustum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Caulophine
Price:
CAS No.:	1159989-19-1
Catalog No.:	CFN91984
Molecular Formula:	C₁₉H₂₁NO₅
Molecular Weight:	343.37 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Caulophyllum robustum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library SOD Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9123 mL	14.5616 mL	29.1231 mL	58.2462 mL	72.8078 mL
5 mM	0.5825 mL	2.9123 mL	5.8246 mL	11.6492 mL	14.5616 mL
10 mM	0.2912 mL	1.4562 mL	2.9123 mL	5.8246 mL	7.2808 mL
50 mM	0.0582 mL	0.2912 mL	0.5825 mL	1.1649 mL	1.4562 mL
100 mM	0.0291 mL	0.1456 mL	0.2912 mL	0.5825 mL	0.7281 mL

CFN89212	Caulophylline B	1359978-55-4	343.37	C₁₉H₂₁NO₅
CFN91984	Caulophine	1159989-19-1	343.37	C₁₉H₂₁NO₅
CFN91008	Atherosperminine	5531-98-6	309.4	C₂₀H₂₃NO₂
CFN00068	Crassifoline methine	133084-00-1	343.42	C₂₀H₂₅NO₄
CFN00085	Lavendustin A	125697-92-9	381.38	C₂₁H₁₉NO₆
CFN00086	Lavendustin B	125697-91-8	365.38	C₂₁H₁₉NO₅
CFN00094	Tribenzylamine	620-40-6	288.41	C₂₁H₂₁N
CFN00095	Trichosanatine	169626-16-8	444.53	C₂₇H₂₈N₂O₄
CFN90113	9-Phenylcarbazole	1150-62-5	243.30	C₁₈H₁₃N
CFN90114	3-Bromo-N-phenylcarbazole	1153-85-1	322.20	C₁₈H₁₂BrN