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Cepharadione A
Cepharadione A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cepharadione A
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CAS No.: 55610-01-0
Catalog No.: CFN96041
Molecular Formula: C18H11NO4
Molecular Weight: 305.3 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Yellow powder
Source: The herbs of Piper longum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cepharadione A is a naturally occurring DNA damaging agent.
Cepharadione A Description
Source: The herbs of Piper longum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2755 mL 16.3773 mL 32.7547 mL 65.5093 mL 81.8867 mL
5 mM 0.6551 mL 3.2755 mL 6.5509 mL 13.1019 mL 16.3773 mL
10 mM 0.3275 mL 1.6377 mL 3.2755 mL 6.5509 mL 8.1887 mL
50 mM 0.0655 mL 0.3275 mL 0.6551 mL 1.3102 mL 1.6377 mL
100 mM 0.0328 mL 0.1638 mL 0.3275 mL 0.6551 mL 0.8189 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Molecules.2013 Mar;18(3):2563-70.
A New Hydroxychavicol Dimer from the Roots of Piper betle.[Reference: WebLink]

METHODS AND RESULTS:
A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and Cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods.
CONCLUSIONS:
Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
CFN91019Roemerine548-08-3279.33C18H17NO2
CFN91767Fissistigine A70420-58-5311.33C18H17NO4
CFN93031Laetanine72361-67-2313.35C18H19NO4
CFN90492Laurolitsine5890-18-6313.34C18H19NO4
CFN99528Norisoboldine23599-69-1313.35C18H19NO4
CFN96271Norglaucine hydrochloride39945-41-0377.9C20H24ClNO4
CFN96155Dehydroformouregine107633-69-2337.4C20H19NO4
CFN894856-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine2101836-45-5367.39C21H21NO5
CFN97889Cassyfiline4030-51-7341.4C19H19NO5
CFN960391,2-Methylenedioxy-3,10,11-trimethoxynoraporphine14050-90-9355.4C20H21NO5
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