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Ciwujiatone
Ciwujiatone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ciwujiatone
Price:
CAS No.: 218901-26-9
Catalog No.: CFN89318
Molecular Formula: C22H26O9
Molecular Weight: 434.44 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Kalimeris integrifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ciwujiatone exhibits significant activities against colon cancer cell lines SW480 and SW620.
In vitro:
Natural Product Research & Development, 2014, 26(6):851-833.
Phenolic Constituents from Rhizome of Wikstroemia indica and Their Anti-tumor Activity.[Reference: WebLink]

METHODS AND RESULTS:
Seventeen phenolic constituents were isolated from the rhizome of Wikstroemia indica using a combination of various chromatographic methods. Their structures were elucidated and identified as wikstromol( 1),matairesinol( 2),syringaresinol( 3),pinoresinol( 4),isolariciresinol( 5),Ciwujiatone( 6),isorhamnetin-3-O-robinobioside( 7),wikstaiwanone A( 8),wikstaiwanone B( 9),kaempferol( 10),rutin( 11),daphnoretin( 12),triumbelletin( 13),alnusdiol( 14),aloe-emodin-8-O-β-D-glucoside( 15),chlorogenic acid( 16) and p-hydroxybenzoic acid( 17) by physicochemical properties and spectral data including NMR and MS. Compounds 3-9 and 13-16 were isolated from this plant for the first time.
CONCLUSIONS:
The anti-tumor tests showed compounds 1-4,6-9 exhibited different activities against colon cancer cell lines SW480 and SW620,in which compound 6 showed most significant activities against the two cell lines.
Ciwujiatone Description
Source: The herbs of Kalimeris integrifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3018 mL 11.5091 mL 23.0181 mL 46.0363 mL 57.5453 mL
5 mM 0.4604 mL 2.3018 mL 4.6036 mL 9.2073 mL 11.5091 mL
10 mM 0.2302 mL 1.1509 mL 2.3018 mL 4.6036 mL 5.7545 mL
50 mM 0.046 mL 0.2302 mL 0.4604 mL 0.9207 mL 1.1509 mL
100 mM 0.023 mL 0.1151 mL 0.2302 mL 0.4604 mL 0.5755 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Res. 2017 Sep 19:1-6.
A new sesquiterpene from Kalimeris integrifolia.[Pubmed: 28927288]

METHODS AND RESULTS:
A new sesquiterpene kalinturoside A (1), and 17 known compounds friedelan-3-ol (2), 24-ethyl-5a-cholesta-7, 22(E)-dien-3-one (3), friedelin (4), syringaresinol (5), α-spinasterol (6), Ciwujiatone (7), syringic acid (8), scopoletin (9), apocynin (10), 1-(3-hydroxy-4, 5-dimethoxyphenyl)ethan-1-one (11), apigenin (12), 5-hydroxymethylfurfural (13), stigmasterol-3-O-β-d-glucopy-ranoside (14), bidenoside C (15), citrusin (16), irioresinol A (17) and syringaresinol-4-O-β-d-glucopyranoside (18) were isolated from the herbs of Kalimeris integrifolia.
CONCLUSIONS:
The structures of these compounds were elucidated using spectroscopic techniques such as NMR and MS. All of the compounds were isolated from this genus for the first time.
Trametenolic acid

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Naringenin

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Santamarine

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Ginkgolide B

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Parkeol

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