1-Dehydro-6-gingerdione | CAS:76060-35-0

1-Dehydro-6-gingerdione

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Product Name	1-Dehydro-6-gingerdione
Price:	$258 / 10mg
CAS No.:	76060-35-0
Catalog No.:	CFN92298
Molecular Formula:	C₁₇H₂₂O₄
Molecular Weight:	290.4 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The rhizomes of Zingber officinale Rosc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $108.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.1-Dehydro-6-gingerdione has antioxidant and anti-inflammatory activities, it significantly suppresses the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion.

Targets:

PGE | NOS | COX

In vitro:

Food Chem. 2012 Nov 15;135(2):332-7.

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.[Pubmed: 22868095]

Hexahydrocurcumin, 1-Dehydro-6-gingerdione, 6-dehydroshogaol and 6-shogaol were evaluated for their antioxidant and anti-inflammatory activities in the present study.
METHODS AND RESULTS:
The relative antioxidant potencies of ginger compounds decreased in similar order of 1-Dehydro-6-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7μM and 6-shogaol of 7μM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14μM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-Dehydro-6-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion.
CONCLUSIONS:
These results contribute to our theoretical understanding of the potential beneficial effects of consuming ginger as a food and/or dietary supplement.

1-Dehydro-6-gingerdione Description

Source:	The rhizomes of Zingber officinale Rosc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Antioxidants Compound Library Phenols Compound Library PGE Inhibitor Library NOS Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4435 mL	17.2176 mL	34.4353 mL	68.8705 mL	86.0882 mL
5 mM	0.6887 mL	3.4435 mL	6.8871 mL	13.7741 mL	17.2176 mL
10 mM	0.3444 mL	1.7218 mL	3.4435 mL	6.8871 mL	8.6088 mL
50 mM	0.0689 mL	0.3444 mL	0.6887 mL	1.3774 mL	1.7218 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	0.6887 mL	0.8609 mL

CFN91045	Paradol	27113-22-0	278.39	C₁₇H₂₆O₃
CFN91531	(E)-[6]-Dehydroparadol	878006-06-5	276.4	C₁₇H₂₄O₃
CFN92299	8-Shogaol	36700-45-5	304.4	C₁₉H₂₈O₃
CFN92300	10-Shogaol	36752-54-2	332.5	C₂₁H₃₂O₃
CFN95838	(3S,5S)-[6]-Gingerdiol	143615-76-3	296.4	C₁₇H₂₈O₄
CFN99931	6-Gingerol	23513-14-6	294.4	C₁₇H₂₆O₄
CFN95833	Methyl-6-gingerol	23513-10-2	308.4	C₁₈H₂₈O₄
CFN99131	8-Gingerol	23513-08-8	322.44	C₁₉H₃₀O₄
CFN95945	5-Methoxy-[8]-gingerol	863780-81-8	336.5	C₂₀H₃₂O₄
CFN99132	10-Gingerol	23513-15-7	350.49	C₂₁H₃₄O₄