Coelonin | CAS:82344-82-9 | Manufacturer ChemFaces

Coelonin

ChemFaces products have been cited in many studies from excellent and top scientific journals

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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $271.6 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Coelonin shows moderate cytotoxic activity against HepG2 cells.

In vitro:

Nat Prod Res. 2017 May 29:1-4.

Phenanthrenes from Arundina graminifolia and in vitro evaluation of their antibacterial and anti-haemolytic properties.[Pubmed: 28553728 ]

Chemical investigation and activity test of Arundina graminifolia led to the isolation of six phenanthrenes: blestriarene A (1), shancidin (2), densiflorol B (3), ephemeranthoquinone (4), Coelonin (5) and lusianthridin (6).
METHODS AND RESULTS:
The isolated compounds demonstrated antibacterial and anti-haemolytic activities. It was found that compounds 1 and 2 had medium antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli, with MICs of 20-40 μg/mL and MBCs of 40-320 μg/mL. Bactericidal mechanisms were explored. Rupture of cell wall and membrane and leakage of nuclear mass were observed by transmission electron microscopy (TEM). Moreover, compounds 1-3 attenuated the erythrocyte damage.
CONCLUSIONS:
Compounds 1 and 2 showed significant anti-haemolytic activity with inhibition rate about 50% at 16 μg/mL.

Nat Prod Res. 2017 Jul;31(13):1518-1522.

Phenolic compounds from the stems of Flickingeria fimbriata.[Pubmed: 28278646]

Chemical investigation of Flickingeria fimbriata (Bl.) Hawkes (Orchidaceae) resulted in the isolation and identification of one new dihydrophenanthrene, 1,2,5,6,7-pentamethoxy-9,10-dihydrophenanthrene (1), together with seven known dihydrophenanthrenes, erianthridin (2), Coelonin (3), 4-methoxy-9,10-dihydrophenanthrene-1,2,7-triol (4), lusianthridin (5), ephemeranthol A (6), flavanthridin (7) and hircinol (8), four known phenanthrenes, epheranthol B (9), nudol (10), denthyrsinin (11) and confusarin (12), and one known bibenzyl, batatasin III (13).
METHODS AND RESULTS:
The structure of the new compound was elucidated by spectroscopic analysis (HRMS, 1D and 2D NMR). All the compounds were isolated from F. fimbriata for the first time except for compounds 5 and 12, and compounds 1, 3, 4, 8, 10, 11 and 13 were obtained from this genus for the first time. Compounds 1-4 showed moderate cytotoxic activity against HepG2 cells.

Coelonin Description

Source:	The herbs of Bletilla striata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhongguo Zhong Yao Za Zhi. 2015 Feb;40(4):679-85.

Chemical constituents of Osmanthus fragrans.[Pubmed: 26137690]

By Silica gel, Sephadex LH-20 and other materials for isolation and purification and by physicochemical methods and spectral analysis for structural identification, 32 compounds were isolated and identified from ethyl acetate portion of alcohol extract of the Osmanthus fragrans.
METHODS AND RESULTS:
Their structures were identified as boschniakinic acid (1), ursolaldehyde (2), augustic acid (3), arjunolic acid (4), 5-hydroxymethyl-2-furancarboxaldehyde (5), isoscutellarein (6), 6, 7-dihydroxycoumarin (7), 2α-hydroxy-oleanolic acid (8), quercetin-3-0-β-D-glu-copyranoside (9), D-allito (10), 5, 4'-dihydroxy-7- methoxyflavone-3-0-β-D-glucopyranoside (11), 5,7-dihydroxychromone (12), lupeol (13), naringenin (14), acetyloleanolic acid (15), chlorogenic acid (16), kaempferol-3-0-β- D-glucopyranoside (17), oleanolic acid (18), kaempferol-3-0-β-D-galactopyanoside (19), 3', 7-dihydroxy-4'-methoxyisoflavon (20), ergosta-4,6,8 (14), 22-tetraen-3-one (21), p-hydroxycinnamic acid (22), syringaresinol (23), 3,4-dihydroxyacetophenonel (24), β-sitosterol (25), ethyl p-hydroxyphenylacetate (26), benzoic acid (27), caffeic acid (28), Coelonin (29), p-hydorxy-phenylacetic acid (30), p-hydroxyacetophenone (31), and methyl-p-hydroxphenylacetate (32). Except for compounds 2, 4, 5, 8-11, 13, 15, 18, 20, 25, and 27, the rest were isolated from the Osmanthus fragrans for the first time.

Product Name	Coelonin
Price:	$388 / 5mg
CAS No.:	82344-82-9
Catalog No.:	CFN92693
Molecular Formula:	C₁₅H₁₄O₃
Molecular Weight:	242.3 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Bletilla striata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1271 mL	20.6356 mL	41.2712 mL	82.5423 mL	103.1779 mL
5 mM	0.8254 mL	4.1271 mL	8.2542 mL	16.5085 mL	20.6356 mL
10 mM	0.4127 mL	2.0636 mL	4.1271 mL	8.2542 mL	10.3178 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	1.6508 mL	2.0636 mL
100 mM	0.0413 mL	0.2064 mL	0.4127 mL	0.8254 mL	1.0318 mL

CFN97236	Usnic acid	7562-61-0	344.3	C₁₈H₁₆O₇
CFN95473	Baishouwubenzophenone	115834-34-9	302.3	C₁₆H₁₄O₆
CFN96398	(Z)-3-Hydroxy-5-methoxystilbene	143207-76-5	226.3	C₁₅H₁₄O₂
CFN95330	New compound 7	N/A	226.3	C₁₅H₁₄O₂
CFN92784	Lusianthridin	87530-30-1	242.3	C₁₅H₁₄O₃
CFN92693	Coelonin	82344-82-9	242.3	C₁₅H₁₄O₃
CFN91418	Batatasin I	51415-00-0	284.3	C₁₇H₁₆O₄
CFN92692	Flavidinin	83925-00-2	254.3	C₁₆H₁₄O₃
CFN92691	Agrostophyllidin	178439-50-4	284.3	C₁₇H₁₆O₄
CFN92781	Phoyunnanin C	956344-38-0	482.5	C₃₀H₂₆O₆