Conduritol A | CAS:526-87-4 | Manufacturer ChemFaces

Conduritol A

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Description:

Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting cataracts through the inhibition of lens aldose reductase.

Targets:

TNF-α | Lens aldose reductase

In vivo:

Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5.

Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre[Pubmed: 19294862]

To investigates the mechanism of hypooglycemic effect of Conduritol A of stems of Gymnema sylvestre.
METHODS AND RESULTS:
Fourteen days later after administration, observation is taken on the change of these mice and rats weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also detected with enzymology method and Radioimmuoassay method. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet beta-cell. Calulate thymus, pancreas, splenica index. Compared with diabetic model mice, high and middosage of Conduritol A could remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P < 0.01). Significantly increase the level of serum insulin (P < 0.05). Activity of SOD was obviously increased, and amount of MDA was obviously decreased (P < 0.05). The amount of Conduritol A disposal of glucose was obviously increased (P < 0.05). Significantly increase thymus, pancreas, splencia index (P < 0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell structure and form of Conduritol A had been some way improved. The immunohistochemistry results showed that beta-cells numbers of pancreas in each Conduritol A group were more than those in the model group.
CONCLUSIONS:
Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger.

Conduritol A Description

Source:	The barks of Marsdenia condurango
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Biosci.Biotech. Biochem.,1994, 58(4):756-7.

Effect of Conduritol A, a Polyol from Gymnema sylvestre, on the Development of Diabetic Cataracts in Streptozotocin-treated Rats and on Aldose Reductase.[Reference: WebLink]

METHODS AND RESULTS:
Streptozotocin-diabetic rats were maintained on a stock diet for 16 weeks and some were given Conduritol A (10 mg/kg/day). The administration of Conduritol A, having a hypoglycemic effect, markedly prevented the diabetic rats from getting cataracts. In practice, Conduritol A inhibited aldose reductase (EC 1.1.1.21) that is capable of catalyzing the conversion of aldoses to sugar alcohols in the polyol pathway. In an in vitro assay, lens aldose reductase was most effectively inhibited by Conduritol A when α,β-d-glucose was used as a substrate. Some enzymes from the rats were not inhibited by Conduritol A. Neither an intraperitoneal injection nor oral dosage of Conduritol A caused acute toxicity in the rats.
CONCLUSIONS:
These findings suggest that the inhibition of lens aldose reductase by Conduritol A may be responsible for its cataract-suppressing effect.

Product Name	Conduritol A
Price:	$258 / 10mg
CAS No.:	526-87-4
Catalog No.:	CFN98868
Molecular Formula:	C₆H₁₀O₄
Molecular Weight:	146.1 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Oil
Source:	The barks of Marsdenia condurango
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antihyperglycemic Compound Library Immunomodulators Compound Library Anti-diabetic retinopathy Compound Library Miscellaneous Compound Library TNF-α Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.8446 mL	34.2231 mL	68.4463 mL	136.8925 mL	171.1157 mL
5 mM	1.3689 mL	6.8446 mL	13.6893 mL	27.3785 mL	34.2231 mL
10 mM	0.6845 mL	3.4223 mL	6.8446 mL	13.6893 mL	17.1116 mL
50 mM	0.1369 mL	0.6845 mL	1.3689 mL	2.7379 mL	3.4223 mL
100 mM	0.0684 mL	0.3422 mL	0.6845 mL	1.3689 mL	1.7112 mL

CFN98778	vibo-Quercitol	488-76-6	164.2	C₆H₁₂O₅
CFN91718	Inositol	87-89-8	180.16	C₆H₁₂O₆
CFN95609	(E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol	1391715-18-6	340.3	C₁₆H₂₀O₈
CFN99044	D-Pinitol	10284-63-6	194.2	C₇H₁₄O₆
CFN90586	L-Quebrachitol	642-38-6	194.18	C₇H₁₄O₆
CFN98868	Conduritol A	526-87-4	146.1	C₆H₁₀O₄
CFN99930	D-(-)-Quinic acid	77-95-2	192.17	C₇H₁₂O₆
CFN99436	Shikimic acid	138-59-0	174.2	C₇H₁₀O₅
CFN99852	3,4-O-Isopropylidene shikimic acid	183075-03-8	214.2	C₁₀H₁₄O₅
CFN92951	3-O-Caffeoylshikimic acid	180981-12-8	336.29	C₁₆H₁₆O₈