Coronalolide methyl ester | CAS:268214-50-2

Coronalolide methyl ester

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Product Name	Coronalolide methyl ester
Price:
CAS No.:	268214-50-2
Catalog No.:	CFN98316
Molecular Formula:	C₃₁H₄₄O₅
Molecular Weight:	496.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Gardenia sootepensis hutchins.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of human cancer cell lines.

Targets:

HIV

In vitro:

Tetrahedron,2004, 60(7):1517-23.

Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera[Reference: WebLink]

METHODS AND RESULTS:
Two new natural cycloartanes, tubiferolide methyl ester (1) and tubiferaoctanolide (2), together with the known coronalolide (3) and Coronalolide methyl ester (4) have been isolated from leaves and twigs of Gardenia tubifera. In addition, a new flavone 5,3′,5′-trihydroxy-7,4′-dimethoxyflavone (5), five known flavones 6–10 and hexacosyl 4′-hydroxy-trans-cinnamate (11) were also obtained from the same source. The structures were assigned on the basis of spectroscopic methods.
CONCLUSIONS:
Compounds 3, 7, 9, and 10 showed significant cytotoxic activities only in P-388 cell line. Compound 1 was cytotoxic against P-388, KB, Col-2 and Lu-1, while 4 was active in P-388 and BCA-1. Compounds 3 and 4 displayed significant anti-HIV activities in the HIV-1RT assay; compound 7 showed moderate activity in this assay. Compounds 5–10 were also found to be active in the ΔTat/RevMC 99 syncytium assay.

Coronalolide methyl ester Description

Source:	The herbs of Gardenia sootepensis hutchins.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Tetrahedron,1997,28(18):529-38.

Novel cytotoxic ring-a seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis[Reference: WebLink]

METHODS AND RESULTS:
Coronalolide methyl ester (1), coronalolide (2), and coronalolic acid (3) were isolated from the leaves and/or stems of Gardenia coronaria. A further compound, methyl coronalolate acetate (4), was purified from the stems after methylation. The novel compounds 1–4 have the rare ring-A seco-cycloartane carbon skeleton and their structures were assigned on the basis of spectral data and molecular modeling, as well as X-ray crystallography performed on 1.
CONCLUSIONS:
Compounds 1 and 2 were also isolated from the leaves of Gardenia sootepensis and showed broad cytotoxic activity when evaluated against a panel of human cancer cell lines.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Cytotoxic Compound Library Triterpenoids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0133 mL	10.0664 mL	20.1329 mL	40.2658 mL	50.3322 mL
5 mM	0.4027 mL	2.0133 mL	4.0266 mL	8.0532 mL	10.0664 mL
10 mM	0.2013 mL	1.0066 mL	2.0133 mL	4.0266 mL	5.0332 mL
50 mM	0.0403 mL	0.2013 mL	0.4027 mL	0.8053 mL	1.0066 mL
100 mM	0.0201 mL	0.1007 mL	0.2013 mL	0.4027 mL	0.5033 mL

CFN96745	24-Hydroxy-25-ethoxy-3,4-secocycloart-4(28)-en-3-oic acid methyl ester	1392210-81-9	516.80	C₃₃H₅₆O₄
CFN98318	Coronalolic acid	268214-52-4	470.7	C₃₀H₄₆O₄
CFN89388	Gardenoin J	1345109-46-7	488.69	C₃₀H₄₈O₅
CFN99255	Sootepin D	1154518-97-4	484.7	C₃₁H₄₈O₄
CFN98317	Coronalolide	268214-51-3	482.7	C₃₀H₄₂O₅
CFN98316	Coronalolide methyl ester	268214-50-2	496.7	C₃₁H₄₄O₅
CFN89422	26-O-Acetylsootepin A	1772588-99-4	540.73	C₃₃H₄₈O₆
CFN90253	Nigranoic acid	39111-07-4	470.69	C₃₀H₄₆O₄
CFN90451	Schisanlactone E	136040-43-2	468.67	C₃₀H₄₄O₄
CFN97492	Secaubrytriol	925932-10-1	490.7	C₃₀H₅₀O₅