Isoescin IA | CAS:219944-39-5 | Manufacturer ChemFaces

Isoescin IA

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $171.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Trachelogenin

Catalog No: CFN90598
CAS No: 34209-69-3
Price: $318/10mg

Sanguinarine

Catalog No: CFN98259
CAS No: 2447-54-3
Price: $30/20mg

Quercetin

Catalog No: CFN99272
CAS No: 117-39-5
Price: $40/20mg

Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg

Spinosin

Catalog No: CFN99600
CAS No: 72063-39-9
Price: $80/20mg

3-Butylidenephthalide

Catalog No: CFN99588
CAS No: 551-08-6
Price: $40/20mg

Alpinumisoflavone

Catalog No: CFN98440
CAS No: 34086-50-5
Price: $ /

Dicentrine

Catalog No: CFN92331
CAS No: 517-66-8
Price: $ / mg

Cyanidin-3-O-rutinoside chloride

Catalog No: CFN92135
CAS No: 18719-76-1
Price: $298/10mg

Taurine

Catalog No: CFN00020
CAS No: 107-35-7
Price: $ /

Description:

Escin Ia and Isoescin IA have been traditionally used clinically as the chief active ingredients of escin, a major triterpene saponin isolated from horse chestnut (Aesculus hippocastanum) seeds for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema.

In vivo:

J Ethnopharmacol. 2012 Jan 6;139(1):201-6.

Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat.[Pubmed: 22094055 ]

Escin Ia and Isoescin IA have been traditionally used clinically as the chief active ingredients of escin, a major triterpene saponin isolated from horse chestnut (Aesculus hippocastanum) seeds for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema. To establish a sensitive LC-MS/MS method and investigate the pharmacokinetic properties of escin Ia and Isoescin IA in rats and the pharmacokinetics difference of sodium escinate with pure escin Ia and Isoescin IA. The absolute bioavailability of escin Ia and Isoescin IA and the bidirectional interconversion of them in vivo were also scarcely reported.
METHODS AND RESULTS:
Wister rats were administrated an intravenous (i.v.) dose (1.7 mg/kg) of sodium escinate (corresponding to 0.5mg/kg of escin Ia and 0.5mg/kg of Isoescin IA, respectively) and an i.v. dose (0.5mg/kg) or oral dose (4mg/kg) of pure escin Ia or Isoescin IA, respectively. At different time points, the concentrations of escin Ia and Isoescin IA in rat plasma were determined by LC-MS/MS method. Main pharmacokinetic parameters including t(1/2), MRT, CL, V(d), AUC and F were estimated by non-compartmental analysis using the TopFit 2.0 software package (Thomae GmbH, Germany) and statistical analysis was performed using the Student's t-test with P<0.05 as the level of significance. After administration of sodium escinate, the t(1/2) and MRT values for both escin Ia and Isoescin IA were larger than corresponding values for the compounds given alone. Absorption of escin Ia and Isoescin IA was very low with F values both <0.25%. Escin Ia and Isoescin IA were found to form the other isomer in vivo with the conversion of escin Ia to Isoescin IA being much extensive than from Isoescin IA to escin Ia.
CONCLUSIONS:
Comparison of the pharmacokinetics of escin Ia and Isoescin IA given alone and together in rat suggest that administration of herbal preparations of escin for clinical use may provide longer duration of action than administration of single isomers. The interconversion of escin Ia and Isoescin IA when given alone indicates that administration of one isomer leads to exposure to the other.

Isoescin IA Description

Source:	The herbs of Aesculus hippocastanum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Adv Pharm Bull. 2015 Nov;5(4):587-91.

Determination of Four Major Saponins in Skin and Endosperm of Seeds of Horse Chestnut (Aesculus Hippocastanum L.) Using High Performance Liquid Chromatography with Positive Confirmation by Thin Layer Chromatography.[Pubmed: 26819933]

To separate and quantify four major saponins in the extracts of the skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum L.) using ultrasonic solvent extraction followed by a high performance liquid chromatography-diode array detector (HPLC-DAD) with positive confirmation by thin layer chromatography (TLC).
METHODS AND RESULTS:
The saponins: escin Ia, escin Ib, Isoescin IA and isoescin Ib were extracted using ultrasonic extraction method. The optimized extraction conditions were: 70% methanol as extraction solvent, 80 °C as extraction temperature, and the extraction time was achieved in 4 hours. The HPLC conditions used: Zorbax SB-ODS-(150 mm × 2.1 mm, 3 μm) column, acetonitrile and 0.10% phosphoric acid solution (39:61 v/v) as mobile phase, flow rate was 0.5 mL min-1 at 210 nm and 230 nm detection. The injection volume was 10 μL, and the separation was carried out isothermally at 30 °C in a heated chamber. Results: The results indicated that the developed HPLC method is simple, sensitive and reliable. Moreover, the content of escins in seeds decreased by more than 30% in endosperm and by more than 40% in skin upon storage for two years.
CONCLUSIONS:
This assay can be readily utilized as a quality control method for horse chestnut and other related medicinal plants.

Product Name	Isoescin IA
Price:	$238 / 20mg
CAS No.:	219944-39-5
Catalog No.:	CFN90932
Molecular Formula:	C₅₅H₈₆O₂₄
Molecular Weight:	1131.3 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Aesculus hippocastanum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.8839 mL	4.4197 mL	8.8394 mL	17.6788 mL	22.0985 mL
5 mM	0.1768 mL	0.8839 mL	1.7679 mL	3.5358 mL	4.4197 mL
10 mM	0.0884 mL	0.442 mL	0.8839 mL	1.7679 mL	2.2098 mL
50 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.3536 mL	0.442 mL
100 mM	0.0088 mL	0.0442 mL	0.0884 mL	0.1768 mL	0.221 mL

CFN96104	3-(4-Methoxyphenyl)-1-(pyrrol-1-yl)propan-1-one	448905-82-6	229.3	C₁₄H₁₅NO₂
CFN99136	Ononin	486-62-4	430.4	C₂₂H₂₂O₉
CFN96651	Sulochrin	519-57-3	332.30	C₁₇H₁₆O₇
CFN92856	Tecomin	31002-27-4	344.3	C₁₅H₂₀O₉