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Coronarin B
Coronarin B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Coronarin B
Price:
CAS No.: 119188-38-4
Catalog No.: CFN99303
Molecular Formula: C20H30O4
Molecular Weight: 334.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The rhizomes of Hedychium coronarium
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Coronarin B has cytotoxic activity, it also has modest antiplasmodial activity.
Targets: Antifection
In vitro:
Planta Med. 2002 Jul;68(7):642-4.
Antiplasmodial activity of labdanes from Aframomum latifolium and Aframomum sceptrum.[Pubmed: 12143001]

METHODS AND RESULTS:
Bioguided fractionation of extracts of Aframomum latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-( S)-nerolidol and seven labdanes, Coronarin B, galanal A and B, galanolactone, ( E)-8beta,17-epoxylabd-12-ene-15,16-dial, (+)-( E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact.
CONCLUSIONS:
The labdanes show a modest in vitro activity against a chloroquine-sensitive Plasmodium falciparum strain.
Coronarin B Description
Source: The rhizomes of Hedychium coronarium
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9895 mL 14.9477 mL 29.8954 mL 59.7907 mL 74.7384 mL
5 mM 0.5979 mL 2.9895 mL 5.9791 mL 11.9581 mL 14.9477 mL
10 mM 0.299 mL 1.4948 mL 2.9895 mL 5.9791 mL 7.4738 mL
50 mM 0.0598 mL 0.299 mL 0.5979 mL 1.1958 mL 1.4948 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5979 mL 0.7474 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry,1994,37(5): 1383-1388.
Labdane diterpenes from rhizomes of Hedychium coronarium[Reference: WebLink]

METHODS AND RESULTS:
Three new labdane diterpenes were isolated together with four known diterpenes [(E)-labda-8(17),12-diene-15,16-dial, Coronarin B and D, and isocoronarin D] from rhizomes of Hedychium coronarium.
CONCLUSIONS:
The structures of the new compounds were determined by spectroscopic evidence to be labda-8(17), 11,13-trien-15(16)-olide, an ester of labda-8(17), 11,13-trien-15-al-16-oic acid and isocoronarin D, and 7β-hydroxyCoronarin B.
Planta Med., 1988, 54(54):311-5.
Cytotoxic Diterpenes from the Rhizomes of Hedychium coronarium[Reference: WebLink]

METHODS AND RESULTS:
Four new labdane-type diterpenes, Coronarin A, Coronarin B, Coronarin C, and Coronarin D, and one known labdane-type diterpene, (E)-labda-8(17), 12- diene-15, 16-dial were isolated as cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. The structures were established by chemical and spectroscopic methods.
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