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Corynoxidine
Corynoxidine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Corynoxidine
Price: $288 / 20mg
CAS No.: 57906-85-1
Catalog No.: CFN96484
Molecular Formula: C21H25NO5
Molecular Weight: 371.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Stephania epigaea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $85.5 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. It inhibits acetylcholinesterase activity in a dose-dependent manner, and the IC50 value of 89.0 microM.
Targets: Antifection | AChR
In vitro:
J Asian Nat Prod Res. 2013;15(3):315-8.
A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera.[Pubmed: 23418880 ]

METHODS AND RESULTS:
A new denitroaristolochic acid, demethylaristofolin C (1), together with six known alkaloids, crebanine N-oxide (2), (-)-sukhodianine-β-N-oxide (3), palmatine (4), corydalmine (5), dehydrocorydalmine (6), and Corynoxidine (7), was isolated from the tubers of Stephania succifera. The structure of demethylaristofolin C was elucidated by spectroscopic techniques (UV, IR, 1D, and 2D NMR) and HR-ESI-MS analyses.
CONCLUSIONS:
These compounds exhibited antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.
Corynoxidine Description
Source: The roots of Stephania epigaea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6925 mL 13.4626 mL 26.9251 mL 53.8503 mL 67.3129 mL
5 mM 0.5385 mL 2.6925 mL 5.385 mL 10.7701 mL 13.4626 mL
10 mM 0.2693 mL 1.3463 mL 2.6925 mL 5.385 mL 6.7313 mL
50 mM 0.0539 mL 0.2693 mL 0.5385 mL 1.077 mL 1.3463 mL
100 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.5385 mL 0.6731 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Arch Pharm Res. 2004 Nov;27(11):1127-31.
Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa.[Pubmed: 15595415]

METHODS AND RESULTS:
In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, Corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa. Structures of these compounds were elucidated on the basis of spectroscopic techniques.
CONCLUSIONS:
These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the IC50 values of compounds 1-4 were 89.0, 16.1, 5.8, and 3.3 microM, respectively.
CFN98384Corydalmine30413-84-4341.4 C20H23NO4
CFN98810Canadine5096-57-1339.4 C20H21NO4
CFN99195Rotundine10097-84-4355.42C21H25NO4
CFN99553Tetrahydropalmatine2934-97-6355.42C21H25NO4
CFN96484Corynoxidine57906-85-1371.4C21H25NO5
CFN89271Epicorynoxidine58000-48-9371.43C21H25NO5
CFN95204N-Methylcorydalmine81010-29-9355.4C21H25NO4
CFN90188D-Tetrahydropalmatine3520-14-7355.41C21H25NO4
CFN90416Tetrahydrocoptisine7461-02-1323.12C19H17NO4
CFN96656Stylopine hydrochloride96087-21-7359.81C19H18ClNO4
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