Coumarin VI | CAS:38215-36-0 | Manufacturer ChemFaces

Coumarin VI

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Size /Price /Stock	10 mM * 1 mL in DMSO / $10.8 / In-stock
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Description:

Coumarin VI is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.

In vitro:

Analyst. 2011 May 21;136(10):2161-7.

Coumarin 6 and 1,6-diphenyl-1,3,5-hexatriene (DPH) as fluorescent probes to monitor protein aggregation.[Pubmed: 21445407]

We report the use of Coumarin 6(Coumarin VI) and 1,6-diphenyl-1,3,5-hexatriene (DPH) for the identification of protein aggregates for the first time. The two dyes can be used at very low (nanomolar) concentrations and do not interfere with the aggregation process, as is reported for other commonly used fluorescent protein probes. In the presence of protein aggregates, their quantum yields are significantly high. DPH is able to recognize both amorphous and fibrillar aggregates but cannot distinguish between them. Coumarin 6(Coumarin VI) can distinguish between both types of aggregates. It also exhibits the characteristic sigmoidal curve of amyloid formation, with higher sensitivity for detection of fibrillation than the conventionally used Thioflavin T.

Coumarin VI Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Coumarin VI
Price:	$30 / 20mg
CAS No.:	38215-36-0
Catalog No.:	CFN90951
Molecular Formula:	C₂₀H₁₈N₂O₂S
Molecular Weight:	350.44 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Pigments Compound Library Diagnostic markers Compound Library Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8536 mL	14.2678 mL	28.5356 mL	57.0711 mL	71.3389 mL
5 mM	0.5707 mL	2.8536 mL	5.7071 mL	11.4142 mL	14.2678 mL
10 mM	0.2854 mL	1.4268 mL	2.8536 mL	5.7071 mL	7.1339 mL
50 mM	0.0571 mL	0.2854 mL	0.5707 mL	1.1414 mL	1.4268 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	0.5707 mL	0.7134 mL

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