Cichoriin | CAS:531-58-8 | Manufacturer ChemFaces

Cichoriin

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Description:

Cichoriin is a photosensitive compound, it could be used as herbal photosensitizing agent in treating benign breast tumor in rats.

In vitro:

International Journal of Biological Chemistry, 2009, 3(1):11-17.

Cytoprotective Activity of Chemical Constituents Isolated from Streptomyces sp.[Reference: WebLink]

METHODS AND RESULTS:
Four flavonoids including kaempferol (1), isoscutellarin (2), umbelliferone (3) and Cichoriin (4) have been isolated from Streptomyces sp. Tc052, an endophyte in the root tissue of Alpinia galanga Swartz. The evaluation for protective effect of compounds 1-4 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was conducted, Compounds 1 and 2 showed significant effective protection ratios of 62.4+2.8 and 55.3+3.4%, respectively, at a concentration of 100 μM, whereas compounds 3-4 were inactive. Compounds 1 and 2 showed potent scavenging effects on DPPH radical exhibiting IC50 value of 60.74 and 75.65 μM, respectively.
CONCLUSIONS:
These results suggest that compounds 1 and 2 may possess the neuroprotective activity against oxdative cellular injuries.

In vivo:

Electromagn Biol Med. 2012 Dec;31(4):299-309.

Introducing Cichorium Pumilum as a potential therapeutical agent against drug-induced benign breast tumor in rats.[Pubmed: 22812448]

Cichorium Pumilum (chicory) is could be a promising cancer treatment in which a photosensitizing drug concentrates in benign tumor cells and activated by quanta at certain wavelength. Such activated extracts could lead to cell death and tumor ablation. Previous studies have shown that Cichorium Pumilum (chicory) contains photosensitive compounds such as Cichoriin, anthocyanins, lactucin, and Lactucopicrin.
METHODS AND RESULTS:
In the present study, the protective effect of sun light-activated Cichorium against the dimethylbenz[a]anthracene (DMBA) induced benign breast tumors to female Sprague-Dawley rats was investigated. Chicory's extract has significantly increase P.carbonyl (PC) and malondialdehyde (MDA) and decreases the hepatic levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) in benign breast tumors-induced group compared to control. It also significantly decrease the number of estrogen receptors ER-positive cells in tumor masses.
CONCLUSIONS:
These results suggest that chicory extracts could be used as herbal photosensitizing agent in treating benign breast tumor in rats.

Cichoriin Description

Source:	The roots of Cichorium intybus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cichoriin
Price:	$100 / 20mg
CAS No.:	531-58-8
Catalog No.:	CFN95196
Molecular Formula:	C₁₅H₁₆O₉
Molecular Weight:	340.3 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Cichorium intybus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9386 mL	14.6929 mL	29.3858 mL	58.7717 mL	73.4646 mL
5 mM	0.5877 mL	2.9386 mL	5.8772 mL	11.7543 mL	14.6929 mL
10 mM	0.2939 mL	1.4693 mL	2.9386 mL	5.8772 mL	7.3465 mL
50 mM	0.0588 mL	0.2939 mL	0.5877 mL	1.1754 mL	1.4693 mL
100 mM	0.0294 mL	0.1469 mL	0.2939 mL	0.5877 mL	0.7346 mL

CFN90593	Daphnetin 7-methyl ether	19492-03-6	192.17	C₁₀H₈O₄
CFN89148	Hydrangetin	485-90-5	192.17	C₁₀H₈O₄
CFN90594	Daphnetin dimethyl ether	2445-80-9	206.19	C₁₁H₁₀O₄
CFN93089	4-Methyldaphnetin	2107-77-9	192.17	C₁₀H₈O₄
CFN91402	7-Methoxy-8-hydroxy-4-methylcoumarin	22084-94-2	206.2	C₁₁H₁₀O₄
CFN93090	5,7-Dihydroxy-4-methylcoumarin	2107-76-8	192.17	C₁₀H₈O₄
CFN99115	6,7-Dihydroxycoumarin	305-01-1	178.14	C₉H₆O₄
CFN93058	4-Methylesculetin	529-84-0	192.17	C₁₀H₈O₄
CFN99114	Esculin	531-75-9	340.28	C₁₅H₁₆O₉
CFN97684	Isoscopoletin	776-86-3	192.17	C₁₀H₈O₄