Cucurbitacin IIb | CAS:50298-90-3 | Manufacturer ChemFaces

Cucurbitacin IIb

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Product Name	Cucurbitacin IIb
Price:	$268 / 20mg
CAS No.:	50298-90-3
Catalog No.:	CFN90376
Molecular Formula:	C₃₀H₄₈O₇
Molecular Weight:	520.70 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The rhizomes of Hemsleya amabilis Diels.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $83.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. Cucurbitacin IIb exhibits its anti-inflammatory activity through modulating multiple cellular behaviors and signaling pathways, leading to the suppression of the adaptive immune response. Cucurbitacin IIb also can induce apoptosis of concanavalin A-activated mouse lymphocytes.

Targets:

IFN-γ | IL Receptor | p38MAPK | JNK | ERK | NF-kB | IkB | TNF-α | p65 | STAT | IKK

In vitro:

PLoS One. 2014 Feb 25;9(2):e89751.

Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes.[Pubmed: 24587010]

Cucurbitacin IIb (CuIIb) is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. However, its action mechanism has not been completely understood. This study aimed to explore the anti-inflammatory activity of Cucurbitacin IIb and its underlying mechanism in mitogen-activated lymphocytes isolated from mouse mesenteric lymph nodes.
METHODS AND RESULTS:
The results showed that Cucurbitacin IIb inhibited the proliferation of concanavalin A (Con A)-activated lymphocytes in a time- and dose-dependent manner. Cucurbitacin IIb treatment arrested their cell cycle in S and G2/M phases probably due to the disruption of the actin cytoskeleton and the modulation of p27(Kip1) and cyclin levels. Moreover, the surface expression of activation markers CD69 and CD25 on Con A-activated CD3(+) T lymphocytes was suppressed by CuIIb treatment. Both Con A- and phorbol ester plus ionomycin-induced expression of TNF-α, IFN-γ and IL-6 proteins was attenuated upon exposure to CuIIb. Mechanistically, Cucurbitacin IIb treatment suppressed the phosphorylation of JNK and Erk1/2 but not p38 in Con A-activated lymphocytes. Although Cucurbitacin IIb unexpectedly enhanced the phosphorylation of IκB and NF-κB (p65), it blocked the nuclear translocation of NF-κB (p65). In support of this, Cucurbitacin IIb significantly decreased the mRNA levels of IκBα and TNF-α, two target genes of NF-κB, in Con A-activated lymphocytes. In addition, Cucurbitacin IIb downregulated Con A-induced STAT3 phosphorylation and increased cell apoptosis.
CONCLUSIONS:
Collectively, these results suggest that Cucurbitacin IIb exhibits its anti-inflammatory activity through modulating multiple cellular behaviors and signaling pathways, leading to the suppression of the adaptive immune response.

Cucurbitacin IIb Description

Source:	The rhizomes of Hemsleya amabilis Diels.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Anti-proliferation Compound Library Triterpenoids Compound Library TNF-α Inhibitor Library STAT Inhibitor Library p65 Inhibitor Library p38MAPK Inhibitor Library NF-kB Inhibitor Library JNK Inhibitor Library IL Receptor Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library IFN-γ Inhibitor Library ERK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9205 mL	9.6025 mL	19.2049 mL	38.4098 mL	48.0123 mL
5 mM	0.3841 mL	1.9205 mL	3.841 mL	7.682 mL	9.6025 mL
10 mM	0.192 mL	0.9602 mL	1.9205 mL	3.841 mL	4.8012 mL
50 mM	0.0384 mL	0.192 mL	0.3841 mL	0.7682 mL	0.9602 mL
100 mM	0.0192 mL	0.096 mL	0.192 mL	0.3841 mL	0.4801 mL

CFN92892	Tetrahydroisocucurbitacin I	3877-89-2	518.68	C₃₀H₄₆O₇
CFN98171	Cucurbitacin IIA	58546-34-2	562.73	C₃₂H₅₀O₈
CFN91760	Cucurbitacin Q1	99530-82-2	560.72	C₃₂H₄₈O₈
CFN92895	Cucurbitacin R	55903-92-9	518.68	C₃₀H₄₆O₇
CFN92140	Dihydrocucurbitacin B	13201-14-4	560.7	C₃₂H₄₈O₈
CFN91586	Fabacein	37710-13-7	600.7	C₃₄H₄₈O₉
CFN92896	Arvenin II	65247-28-1	722.86	C₃₈H₅₈O₁₃
CFN95327	Arvenin III	65597-45-7	678.8	C₃₆H₅₄O₁₂
CFN92893	Hexanorcucurbitacin D	29065-05-2	402.52	C₂₄H₃₄O₅
CFN90209	Cucurbitacin D	3877-86-9	516.67	C₃₀H₄₄O₇