Trametenolic acid | CAS:24160-36-9 | Manufacturer ChemFaces

Trametenolic acid

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Product Name	Trametenolic acid
Price:	$318 / 10mg
CAS No.:	24160-36-9
Catalog No.:	CFN92366
Molecular Formula:	C₃₀H₄₈O₃
Molecular Weight:	456.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The sclerotium of Poria cocos(Schw.)Wolf
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $206.7 / In-stock
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Trametenolic acid Description

Source:	The sclerotium of Poria cocos(Schw.)Wolf
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Evid Based Complement Alternat Med. 2014;2014:259836.

Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells.[Pubmed: 25197307]

METHODS AND RESULTS:
In cells testing, betulin and Trametenolic acid decreased tyrosinase activity and melanin content, while inotodiol and lanosterol significantly increased tyrosinase activity and melanin content, showing an AC⁡50 of 9.74 and 8.43 μM, respectively. Nicotinie acid, 3β,22,25-trihydroxy-lanosta-8-ene, had a little or no effect on tyrosinase. Betulin exhibited a mode of noncompetitive inhibition with a K I = K IS of 0.4 μM on tyrosinase activity showing an IC50 of 5.13 μM and being more effective than kojic acid (6.43 μM), and Trametenolic acid exhibited a mode of mixed inhibition with a K I of 0.9 μM, K IS of 0.5 μM, and an IC50 of 7.25 μM.
CONCLUSIONS:
We proposed betulin and Trametenolic acid as a new candidate of potent tyrosinase inhibitors and inotodiol and lanosterol as accelerators that could be used as therapeutic agent.

Structure Identification:

Phytochem Anal. 2011 Sep-Oct;22(5):419-23.

Rapid isolation and purification of inotodiol and trametenolic acid from Inonotus obliquus by high-speed counter-current chromatography with evaporative light scatting detection.[Pubmed: 21433158]

Inotodiol and Trametenolic acid are considered to be the main bioactive compounds of the fruiting body of the mushroom. These compounds show various biological activities, including anti-tumour, anti-viral, hypoglycaemic, anti-oxidant and cyto-protective. However, effective methods for isolating and purifying inotodiol and Trametenolic acid from the fruiting body of Inonotus obliquus are not currently available. To develop a suitable preparative method in order to isolate inotodiol and Trametenolic acid from a complex Inonotus obliquus extract by preparative high-speed counter-current chromatography (HSCCC).
CONCLUSIONS:
Inotodiol and Trametenolic acid were rapidly isolated and purified from the chloroform extract of Inonotus obliquus (Fr.) by HSCCC with evaporative light scatting detection (ELSD).The target compounds were finally isolated and purified with a solvent system of hexane:ethyl acetate:methanol:water (1:0.4:1:0.4, v/v/v/v). In a single operation, 100 mg of the I. obliquus extracts yielded 13.0 mg of inotodiol and 7.0 mg of Trametenolic acid. The entire separation and purification process took less than 5 h. The purities of obtained inotodiol and Trametenolic acid were 97.51 and 94.04%, respectively.
CONCLUSIONS:
HSCCC-ELSD was an efficient and rapid method for the separation and purification of inotodiol and Trametenolic acid from I. obliquus.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Cytotoxic Compound Library Anti-leishmanial Compound Library Triterpenoids Compound Library Tyrosinase Inhibitor Library

Description:	Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9 μM, K IS of 0.5 μM, and an IC50 of 7.25 μM.Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content.
Targets:	Tyrosinase

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	43.7924 mL	54.7405 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	8.7585 mL	10.9481 mL
10 mM	0.219 mL	1.0948 mL	2.1896 mL	4.3792 mL	5.4741 mL
50 mM	0.0438 mL	0.219 mL	0.4379 mL	0.8758 mL	1.0948 mL
100 mM	0.0219 mL	0.1095 mL	0.219 mL	0.4379 mL	0.5474 mL

CFN90804	3-O-Acetyl-16 alpha-hydroxytrametenolic acid	168293-13-8	514.8	C₃₂H₅₀O₅
CFN90577	Dehydrotrametenolic acid	29220-16-4	454.69	C₃₀H₄₆O₃
CFN90790	16alpha-Hydroxydehydrotrametenolic acid	176390-66-2	470.7	C₃₀H₄₆O₄
CFN90791	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid	168293-14-9	512.7	C₃₂H₄₈O₅
CFN95050	Poricoic acid B	137551-39-4	484.7	C₃₀H₄₄O₅
CFN95056	Poricoic acid G	415724-84-4	486.7	C₃₀H₄₆O₅
CFN89516	Euphol	514-47-6	426.71	C₃₀H₅₀O
CFN91600	Euphorbol	566-14-3	440.7	C₃₁H₅₂O
CFN92368	Lanosterol	79-63-0	426.7	C₃₀H₅₀O
CFN92376	Butyrospermol	472-28-6	426.7	C₃₀H₅₀O