Selaginellin | CAS:941269-84-7 | Manufacturer ChemFaces

Selaginellin

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $388.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Astin C

Catalog No: CFN95189
CAS No: 148057-23-2
Price: $318/10mg

Kaempferol

Catalog No: CFN98838
CAS No: 520-18-3
Price: $30/20mg

Deoxyandrographolide

Catalog No: CFN90518
CAS No: 79233-15-1
Price: $288/20mg

Abietic acid

Catalog No: CFN90587
CAS No: 514-10-3
Price: $40/20mg

Ganodermanondiol

Catalog No: CFN99085
CAS No: 107900-76-5
Price: $318/5mg

Verbasoside

Catalog No: CFN95015
CAS No: 61548-34-3
Price: $318/5mg

Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg

beta-Rhamnocitrin

Catalog No: CFN92328
CAS No: 90-19-7
Price: $ / mg

Methyl caffeate acid

Catalog No: CFN95561
CAS No: 3843-74-1
Price: $ / mg

Proanthocyanidins

Catalog No: CFN99556
CAS No: 4852-22-6
Price: $70/20mg

Description:

Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows inhibitory effect on high glucose-induced cell injury and apoptosis in differentiated PC12 cells, which is related to inhibition of LOX-1/NADPH oxidase-reactive oxygen species/caspase-3 signaling pathway.

Targets:

Caspase | ROS | NADPH-oxidase | LOX

In vitro:

Naunyn Schmiedebergs Arch Pharmacol. 2010 Jan;381(1):73-81.

Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells.[Pubmed: 19936711 ]

L-glutamate plays a key role in neuronal cell death associated with many neurodegenerative conditions such as cerebral ischemia, hypoxia, Alzheimer's, Huntington's, and Parkinson's diseases.
METHODS AND RESULTS:
Selaginellin, a component extracted from Saussurea pulvinata (Hook.et Grev.) Maximo, was assessed for its ability to protect rat pheochromocytoma (PC12) cells against oxidative toxicity induced by glutamate. The differentiated PC12 cells were pretreated with various concentrations (10(-7), 3 x 10(-7), or 10(-6) M) of Selaginellin for 1 h prior to exposure to L-glutamate. Selaginellin was shown to protect PC12 cells against glutamate toxicity, as determined by characteristic morphological features, lactate dehydrogenase release and cell viability, and apoptosis as evaluated by Hoechst 33342 staining assay and caspase-3 activity. In addition, the increase in levels of reactive oxygen species and decrease in klotho gene expression induced by glutamate were significantly reversed by Selaginellin.
CONCLUSIONS:
Our study suggests that Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene.

Selaginellin Description

Source:	The herbs of Selaginella pulvinata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Eur J Pharmacol. 2012 Nov 5;694(1-3):60-8.

Inhibitory effect of selaginellin on high glucose-induced apoptosis in differentiated PC12 cells: role of NADPH oxidase and LOX-1.[Pubmed: 22964466 ]

Hyperglycemia clearly plays a key role in the development and progression of diabetic neuropathy. Hyperglycemia induces oxidative stress to generate reactive oxygen species in diabetic neurons resulting in neuronal damage and dysfunction.Apoptosis has been proposed as a possible mechanism for high glucose-induced neural dysfunction and neuronal cell injury.
METHODS AND RESULTS:
High glucose per se enhances lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression via activation of NADPH oxidase/reactive oxygen species pathway in endothelial cells. Selaginellin, a component extracted from Saussurea pulvinata (Hook. et Grev.) Maxim, was assessed for its ability to protect rat pheochromocytoma (PC12) cells against oxidative toxicity induced by high glucose. The differentiated PC12 cells were pretreated with various concentrations (10(-7), 3×10(-7) or 10(-6) M) of Selaginellin for 1 h and then co-treated with Selaginellin and D-glucose (75 mM) for 72 h. Selaginellin was shown to protect differentiated PC12 cells against high glucose toxicity, as determined by characteristic morphological features, cell viability, and apoptosis as evaluated by Hoechst 33,258 staining assay, annexin V-propidium iodide double staining assay and caspase-3 activity. In addition, the increase in NADPH oxidase activity, mRNA expression of NADPH oxidase subunits (NOX-1 and NOX-2) and LOX-1, and reactive oxygen species production induced by high glucose were significantly inhibited by Selaginellin or by anti-LOX-1 antibody.
CONCLUSIONS:
The present study demonstrated that inhibitory effect of Selaginellin on high glucose-induced cell injury and apoptosis in differentiated PC12 cells is related to inhibition of LOX-1/NADPH oxidase-reactive oxygen species/caspase-3 signaling pathway.

Product Name	Selaginellin
Price:	$338 / 5mg
CAS No.:	941269-84-7
Catalog No.:	CFN95030
Molecular Formula:	C₃₄H₂₄O₅
Molecular Weight:	512.6 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Selaginella pulvinata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library ROS Inhibitor Library NADPH-oxidase Inhibitor Library LOX Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9508 mL	9.7542 mL	19.5084 mL	39.0168 mL	48.771 mL
5 mM	0.3902 mL	1.9508 mL	3.9017 mL	7.8034 mL	9.7542 mL
10 mM	0.1951 mL	0.9754 mL	1.9508 mL	3.9017 mL	4.8771 mL
50 mM	0.039 mL	0.1951 mL	0.3902 mL	0.7803 mL	0.9754 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.3902 mL	0.4877 mL

CFN96560	Dodovisone D	1616683-53-4	414.41	C₂₂H₂₂O₈
CFN90442	Phlorizin dihydrate	7061-54-3	472.44	C₂₁H₂₄O₁₀.₂H₂O
CFN92206	7-Hydroxy-beta-carboline-1-propionic acid	215934-15-9	256.3	C₁₄H₁₂N₂O₃
CFN92247	1-Ketoaethiopinone	105062-36-0	310.4	C₂₀H₂₂O₃